Table 1.

Coreceptor levels and circulating α1PI and α2M in HIV-seronegative volunteers

SubjectSexaα2M concn (μM)bα1PI concn (μM)bLymphocyte (MFI)cMononuclear phagocytes (MFI)c
CD4+CCR5+CXCR4+HLE+CD4+CCR5+CXCR4+HLE+
1M5.651.91053124176162339257
2F5.573.098251011902532112341
3F5.1211.01091132165191742248
4M3.5334.01141771245142150167
5M3.3442.49721109178324363325
6F3.2661.21211350178191519177
7F3.5013.7NDNDNDNDNDNDNDND
8M5.5739.5NDNDNDNDNDNDNDND
  • a M, male; F, female.

  • b Active concentration determined by elastase inhibition.

  • c Geometric mean fluorescence was detected by flow cytometry. Lymphocytes identified by forward and side scatter were gated to represent the CD4+ population. Mononuclear phagocytes identified by forward and side scatter were gated to represent the CD4+ CD14+ population. CCR5, CXCR4, and HLE are represented as the geometric mean fluorescence intensity (MFI) within gated cells. ND, not determined.