Table 2.

Passive immunizationa

Clinical indicationImmunization
Hepatitis AImmunoglobulin may be administered prophylactically (i.m.) at a dose of 0.02 ml/kg if exposure is in ≤2 wk
Hepatitis BHepatitis B immunoglobulin given in 2 doses; the first as soon as possible and the second, 0.06 ml/kg (i.m.), in a mo
MeaslesImmunoglobulin given within 6 days of exposure, 0.25 ml/kg (i.m.) or IVIg, 100–400 mg/kg (higher doses for severely immunocompromised patients)
VaricellaVaricella immunoglobulin from Red Cross Blood Services for i.m. administration (each vial contains 1.25 ml containing about 125 U; suggested maximal dose, 625 U); must be given within 96 h of exposure
RabiesRabies immunoglobulin (from hyperimmunized human donors) given i.m. at 20 IU, with as much as possible infiltrated around the wound and the remainder i.m. with a new needle
TetanusHuman tetanus immunoglobulin in a single dose of 3,000–6,000 U i.m.—some recommend injection of a portion around the site of infection; if not available, IVIg is recommended, though dosage is not known
RSVRespigam at 750 mg/kg i.v. monthly for certain infants with chronic lung disease during RSV season
CMVCytogam at 150 mg/kg for seronegative transplant patients followed by gradually decreased doses every 2 wk for 16 wk
  • a From reference 2.