Table 1.

Mean logarithmic titers obtained by flow assay, killing assay, and ELISA for antisera from adults vaccinated with pneumococcal PS or conjugate vaccine

VaccineSerotypenMLTaobtained by:
Flow assayKilling assayELISA
PrePostPrePostPrePost
23-valent PS6A23NDb0.21ND2.41ND2.30
6B23ND0.37ND2.77ND1.15
19F23ND0.83ND2.64ND1.13
Bivalent conjugate23F46c0.251.320.232.530.522.12
Tetravalent conjugate6B340.251.071.283.500.271.31
19F400.290.340.922.630.391.59
23F400.210.620.882.850.331.54
  • a Mean log10 titers (MLT) were calculated before vaccination (Pre) for conjugate antisera only and after vaccination (Post) for both PS and conjugate vaccine antisera.

  • b ND, not done, because antisera were not available.

  • c MLT for the killing assay was calculated for seven prevaccination and seven postvaccination antisera.