Table 1.

IFN-γ responses of patients with minimal TB andM. bovis-infected cattle to PPD or PPDB, ESAT-6, and CFP10

SubjectIFN-γ responsea
PatientsCattle
PPDESAT-6CFP10PPDBESAT-6CFP10
14,3212,5423,8154.24.73.9
23,565108485.35.01.3
34,7004,4842,0557.46.05.8
45,3767005140.90.80.9
52081341552.20.71.0
610,6753,0518,0030.91.11.8
77,658223,8951.41.00.9
84,5001,75287518.512.814.6
93,9166514140.423.817.8
102,14380184.73.62.7
115,969751,27618.52.81.4
1220,8272,26921528.820.611.6
135,8922,7661,99519.98.21.4
145,8043,3271,28721.712.71.7
155,7971,3183,4676.42.91.4
162,856272952.00.91.0
1716,4184,3726,24818.717.311.4
18543546711.06.40.7
1915,5435,7422,0211.91.22.2
207,28310123430.1271.1
No. of positive respondersb19121215148
  • a IFN-γ measured by ELISA. Results for humans are expressed as mean picograms per milliliter from triplicate wells and are shown as delta values (see Materials and Methods). Results for cattle are expressed as mean ODI values (OD of antigen-stimulated well/OD of control well) from duplicate cultures.

  • b For the TB patient group the cutoff point was an IFN-γ release of >300 pg/ml; for M. bovis-infected cattle the cutoff point was an ODI of >2.