Table 2.

Pharmacokinetics of mouse and human anti-PT IgG antibodies administered both i.v. and i.p. in BALB/c micea

PreparationAnti-PT IgG dose (mg/kg)Observed peak (h)Peak levelb(μg/ml)V (ml)t1/2 (days)
P-IGIV (i.v.)146.6189.34.267.8
P-IGIV (i.p.)146.6338.13.537.0
PHIS (i.p.)181.93101.82.005.8
HuISG (i.p.)4.462.142.336.9
  • a All values reported are geometric means.

  • b The peak P-IGIV administered i.p. was significantly higher than the peak HuISG (P < 0.05).