Table 6.

Effect of timing of P-IGIV on mortality after aerosol challenge in micea

Group50% Mortality (days postchallenge)% Survival postchallenge at:
7 days14 days21 days28 days
Uninfected>28100.0100.0100.0100.0
P-IGIV
 Days 6 and 7>2886.756.753.353.3
 Days 8 and 91178.95.35.35.3
 Days 10 and 1212100.03.33.33.3
 Days 14 and 1813100.00.00.00.0
Saline1292.00.00.00.0
  • a All mice received P-IGIV (1,000 mg/kg). Only P-IGIV administered 6 days after aerosol challenge significantly improved survival compared to the saline group (P < 0.01).