Table 3.

Comparison of anti-PT IgG antibody concentration in P-IGIV doses and with standard IGIVa

IgG antibody (dose [mg/kg])Globulin concn (%)Approximate globulin dose (mg/kg)Anti-PT IgG concn (μg/ml)Anti-PT IgG dose (mg/kg)
P-IGIV (2,800)102,8001,832.550.97
P-IGIV (1,400)51,400916.325.49
P-IGIV (700)2.570045012.74
P-IGIV (350)1.253502256.37
P-IGIV (175)0.6251751123.19
P-IGIV (88)0.312588561.59
Gamimmune41,1005.30.15
  • a All doses of P-IGIV had significantly higher anti-PT IgG levels than did saline (P < 0.01) and Gamimmune (P < 0.05), except for 700-mg/kg P-IGIV (P > 0.05). Globulin and anti-PT IgG doses are based on the mean weight at the day of challenge for all groups (7.2 g) and an administered volume of 0.2 ml.