TABLE 1.

Epidemiology and clinical symptoms of Whipple's diseasea

EpidemiologyFinding
Reported cases1,000
Mean age50 yrs
Sex ratio (male/female)8
Familial casesFew
Major clinical manifestations
    Weight loss90%
    Diarrhea75%
    Arthropathy85%
    Abdominal pain60%
Other symptoms
    Arthralgias, arthritis70-90%
    Anemia75-90%
    Fever45%
    Night sweats
    Lymphadenopathy40-50%
    Hyperpigmentation40-60%
    Cardiac manifestations35-65%
    Pulmonary manifestations35-60%
    CNS manifestations20-30%
    Ocular manifestations5-15%
    Splenomegaly5-10%
  • a Data were collected from references 22, 26, and 77. CNS, central nervous system.