TABLE 2.

Serum antibody responses after two vaginal doses of recombinant CTB in women using different types of contraceptive methods

Immune responseImmunization group
IUDOCPNPC
IgA antitoxin
    Frequencya5/93/87/9
    Prevaccination titerb85 (44-161)34 (12-93)41 (22-73)
    Postvaccination titerc219 (103-468)85 (40-181)300 (94-955)
    Fold increased2.62.57.3
IgG antitoxin
    Frequency4/92/85/9
    Prevaccination titer127 (70-232)138 (77-246)153 (103-227)
    Postvaccination titer238 (119-479)306 (156-603)546 (205-1492)
    Fold increase1.92.23.6
  • a Number of responders per number tested. Responders were defined as having a twofold or greater increase in CTB-specific titers between pre- and postvaccination specimens.

  • b Geometric mean CTB-specific antibody titer (95% confidence interval) before vaccination for the whole group of volunteers.

  • c Geometric mean CTB-specific antibody titer (95% confidence interval) 14 days after the second vaccination for the whole group of volunteers.

  • d Geometric mean titer increase in relation to the prevaccination titers for all subjects.