Table 1.

Decreased CD69 surface expression on activated CD4 and CD8 T lymphocytes in HIV-infected individuals

SampleHealthy individualsHIV-infected individuals
CD4 T lymphocytesCD8 T lymphocytesCD4 T lymphocytesCD8 T lymphocytes
% CD69Anti-CD69 ABC% CD69Anti-CD69 ABC% CD69Anti-CD69 ABC% CD69Anti-CD69 ABC
188131,2978399,2906089,4915831,717
290174,97488119,6225880,2206536,920
380129,73979101,65934103,2724073,386
483179,81084126,1025286,7135352,663
589123,15188101,2476280,6728449,743
692217,49890192,7056556,9157332,491
789138,26089134,4245365,3356747,303
865155,1156495,5923658,8473356,445
975110,9627379,1036977,9928460,495
1088148,93987128,2825086,7617276,680
1176105,4198190,0485475,3896352,768
1261198,44058129,4274359,6425246,621
1363178,78162136,93549130,2146386,031
1464154,31366113,0112683,8773752,170
1564114,4916077,49873134,8936464,984
1690137,5118999,9942434,0415128,244
1784123,08977121,65043105,4066378,218
1885169,59987162,2572956,3844077,197
1994125,87992116,9766794,8747466,515
2084232,37887147,3272747,4794570,725
2171136,66670106,801738,0193865,755
Mean ± SD80 ± 11a 151,729 ± 34,106b 75 ± 18c 118,093 ± 26,865d 47 ± 17a 78,402 ± 26,014b 58 ± 15c 57,480 ± 16,284d
% Decrease41e 48e 23e 51e
  • a CD4 T lymphocytes, percent CD69, normal healthy individuals versus HIV-infected individuals, P< 0.0001.

  • b CD4 T lymphocytes, anti-CD69, ABC normal healthy individuals versus HIV-infected individuals, P< 0.0001.

  • c CD8 T lymphocytes, percent CD69, normal healthy individuals versus HIV-infected individuals, P< 0.0001.

  • d CD8 T lymphocytes, anti-CD69 ABC, normal healthy individuals versus HIV-infected individuals, P< 0.0001.

  • e Percent decrease = [(mean for normal healthy individuals − mean for HIV-infected individuals)/mean for normal healthy individuals] × 100.