RT Journal Article
SR Electronic
T1 Plasma Concentration of Malaria Parasite-Derived Macrophage Migration Inhibitory Factor in Uncomplicated Malaria Patients Correlates with Parasitemia and Disease Severity
JF Clinical and Vaccine Immunology
JO Clin Vaccine Immunol
FD American Society for Microbiology
SP 1524
OP 1532
DO 10.1128/CVI.00149-10
VO 17
IS 10
A1 Han, Cong
A1 Lin, Yahui
A1 Shan, Guangliang
A1 Zhang, Zaixing
A1 Sun, Xiaodong
A1 Wang, Zhensheng
A1 Wei, Chunyan
A1 Deng, Yan
A1 Zhang, Lianhui
A1 Bu, Lingyi
A1 Shao, Dingding
A1 Wang, Heng
YR 2010
UL http://cvi.asm.org/content/17/10/1524.abstract
AB Host macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of malaria infections. Several Plasmodium parasite-derived MIFs were identified to have the potential to regulate host immune response. However, the role of Plasmodium MIFs in the immunopathogenesis of malaria infection and the relationships between these mediators and inflammatory cytokines remained unclear. In this study, we have investigated two Plasmodium MIFs in peripheral blood of uncomplicated malaria patients and analyzed their correlations with several major factors during malaria infection. We found that both Plasmodium falciparum MIF (PfMIF) and Plasmodium vivax MIF (PvMIF) levels in patients were positively correlated with parasitemia, tumor necrosis factor alpha, interleukin-10 (IL-10), and monocyte chemoattractant protein 1 but were not correlated with transforming growth factor β1 and IL-12. Of interest was that the PvMIF level was positively correlated with host body temperature and human MIF (HuMIF) concentrations. Moreover, multiple stepwise regression analysis also showed that parasitemia, IL-10, and HuMIF expression were significant predictors of Plasmodium MIF production. In addition, during antimalarial drug treatment, the decreasing of Plasmodium MIF concentrations was followed by parasitemia in most patients. Our results suggested that the Plasmodium MIF circulating level reflects the level of parasitemia and thus was closely correlated with disease severity in uncomplicated malaria. Therefore, this factor has the potential to be a promising disease predictor and is applicable in clinical diagnosis.