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MICROBIAL IMMUNOLOGY

Time Course of Humoral and Cell-Mediated Immune Responses to Human Papillomavirus Type 16 in Infected Women

Mayumi Nakagawa, Raphael Viscidi, Ian Deshmukh, Maria Da Costa, Joel M. Palefsky, Sepideh Farhat, Anna-Barbara Moscicki
Mayumi Nakagawa
1Departments of Laboratory Medicine
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  • For correspondence: nakagawa@labmed2.ucsf.edu
Raphael Viscidi
2Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Maryland
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Ian Deshmukh
3Pediatrics
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Maria Da Costa
4Stomatology, Schools of Medicine and Dentistry, University of California at San Francisco, San Francisco, California
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Joel M. Palefsky
1Departments of Laboratory Medicine
4Stomatology, Schools of Medicine and Dentistry, University of California at San Francisco, San Francisco, California
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Sepideh Farhat
3Pediatrics
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Anna-Barbara Moscicki
3Pediatrics
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DOI: 10.1128/CDLI.9.4.877-882.2002
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ABSTRACT

The time course of cell-mediated and humoral immune responses was elucidated in eight women with human papillomavirus type 16 (HPV-16) infection by performing serial HPV-16 E6 and E7 cytotoxic T-lymphocyte (CTL) assays and HPV-16 virus-like particle (VLP) antibody analyses. Four subjects had a single incident of HPV-16 DNA detection, and four subjects had two periods of HPV-16 DNA detection. In two of the women in the latter group, the second episode of HPV-16 detection occurred in the presence of high titers of HPV-16 VLP antibody, bringing into question the protective role of humoral immunity in preventing repeated infection. However, all four subjects rapidly became HPV-16 DNA negative following the second detection of HPV-16 DNA, suggesting the presence of immunological memory. In addition, one subject rapidly became negative for HPV-16 DNA despite having no evidence of CTL or VLP antibody response prior to the second HPV-16 DNA detection, suggesting the presence of immunological responses at an undetectable level. Overall, seven of eight subjects (88%) had detectable HPV-16 E6 and/or E7 CTL responses and seven of eight women (88%) had detectable HPV-16 VLP antibody responses.

  • Copyright © 2002 American Society for Microbiology
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Time Course of Humoral and Cell-Mediated Immune Responses to Human Papillomavirus Type 16 in Infected Women
Mayumi Nakagawa, Raphael Viscidi, Ian Deshmukh, Maria Da Costa, Joel M. Palefsky, Sepideh Farhat, Anna-Barbara Moscicki
Clinical and Diagnostic Laboratory Immunology Jul 2002, 9 (4) 877-882; DOI: 10.1128/CDLI.9.4.877-882.2002

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Time Course of Humoral and Cell-Mediated Immune Responses to Human Papillomavirus Type 16 in Infected Women
Mayumi Nakagawa, Raphael Viscidi, Ian Deshmukh, Maria Da Costa, Joel M. Palefsky, Sepideh Farhat, Anna-Barbara Moscicki
Clinical and Diagnostic Laboratory Immunology Jul 2002, 9 (4) 877-882; DOI: 10.1128/CDLI.9.4.877-882.2002
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