IMMUNE-MEDIATED RESPONSES AND DISORDERS

Elucidation of the Cross-Reactive Immunoglobulin M Response to Human Herpesviruses 6 and 7 on the Basis of Neutralizing Antibodies

Mariko Yoshida, Sadayoshi Torigoe, Masao Yamada
DOI: 10.1128/CDLI.9.2.394-402.2002

Article Figures & Data

Figures

  • FIG. 1.
    FIG. 1.

    Titers of NT antibody against HHV-6 and HHV-7 in serum samples sequentially obtained from 36 children.

  • FIG. 2.
    FIG. 2.

    (A) Schematic diagram for categorizing cross-reactivity between antigen and antibody in heterologous viruses such as HHV-6 and HHV-7. (B) Cross-reaction of humoral antibody responses between HHV-6 and HHV-7.

  • FIG. 3.
    FIG. 3.

    HHV-6 infection followed by HHV-7 infection. Seroconversion against HHV-6 is positive and that against HHV-7 is negative. Symbols: ★, weak cross-reaction; shaded ellipse encircled with a dashed line, IgM positive samples. OD, optical density.

  • FIG. 4.
    FIG. 4.

    HHV-6 infection followed by HHV-7 infection. Seroconversion against HHV-6 is positive and that against HHV-7 is also positive. Symbols: ★, cross-reaction; shaded ellipse encircled with a dashed line, IgM positive samples. OD, optical density.

  • FIG. 5.
    FIG. 5.

    HHV-6 infection followed by HHV-7 infection. Seroconversion against HHV-6 and HHV-7 are positive. ★, marked cross-reaction.

  • FIG. 6.
    FIG. 6.

    HHV-7 infection followed by HHV-6 infection. In two cases, patients 11 and 20, seroconversion against HHV-7 and HHV-6 are positive. In the case of patient 35, seroconversion against HHV-7 is positive and that against HHV-6 is negative. Symbols: ★, markedly weak cross-reaction; shaded ellipse encircled with a dashed line, IgM-positive samples.

  • FIG. 7.
    FIG. 7.

    The IgM cross-reactive responses between HHV-6 and HHV-7 are summarized.

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