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MICROBIAL IMMUNOLOGY

Insecticide-Treated Bed Nets Reduce Plasma Antibody Levels and Limit the Repertoire of Antibodies to Plasmodium falciparumVariant Surface Antigens

Nikolaj Askjaer, Caroline Maxwell, William Chambo, Trine Staalsoe, Morten Nielsen, Lars Hviid, Chris Curtis, Thor G. Theander
Nikolaj Askjaer
Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark; London School of Hygiene and
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Caroline Maxwell
Tropical Medicine, London, United Kingdom; and
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William Chambo
National Institute of Medical Research, Amani Medical Research Centre, Amani, Tanzania
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Trine Staalsoe
Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark; London School of Hygiene and
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Morten Nielsen
Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark; London School of Hygiene and
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Lars Hviid
Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark; London School of Hygiene and
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Chris Curtis
Tropical Medicine, London, United Kingdom; and
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Thor G. Theander
Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark; London School of Hygiene and
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DOI: 10.1128/CDLI.8.6.1289-1291.2001
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ABSTRACT

The use of insecticide-treated bed nets (ITN) has been documented to reduce malaria morbidity and mortality in areas with endemic malaria, but concerns have been raised that ITN usage could affect the acquisition of malaria immunity. Several lines of evidence have indicated that antibodies against variant surface antigens (VSA) are important in the development of naturally acquired immunity toPlasmodium falciparum malaria and may thus be good indicators of immune status. We have compared the levels of VSA antibodies in plasma from children who have used ITN for 4 years to levels in plasma from children from a nearby village not using ITN. A total of 97 plasma samples were analyzed using 13 different P. falciparum isolates. We found that the children using ITN had significantly lower VSA antibody levels and recognized a smaller proportion of the VSA expressed by the tested parasite isolates than children not using ITN.

  • Copyright © 2001 American Society for Microbiology
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Insecticide-Treated Bed Nets Reduce Plasma Antibody Levels and Limit the Repertoire of Antibodies to Plasmodium falciparumVariant Surface Antigens
Nikolaj Askjaer, Caroline Maxwell, William Chambo, Trine Staalsoe, Morten Nielsen, Lars Hviid, Chris Curtis, Thor G. Theander
Clinical and Diagnostic Laboratory Immunology Nov 2001, 8 (6) 1289-1291; DOI: 10.1128/CDLI.8.6.1289-1291.2001

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Insecticide-Treated Bed Nets Reduce Plasma Antibody Levels and Limit the Repertoire of Antibodies to Plasmodium falciparumVariant Surface Antigens
Nikolaj Askjaer, Caroline Maxwell, William Chambo, Trine Staalsoe, Morten Nielsen, Lars Hviid, Chris Curtis, Thor G. Theander
Clinical and Diagnostic Laboratory Immunology Nov 2001, 8 (6) 1289-1291; DOI: 10.1128/CDLI.8.6.1289-1291.2001
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