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Immunological Effects of Interleukin-2 Therapy in Human Immunodeficiency Virus-Positive Subjects

Paolo De Paoli
Paolo De Paoli
Microbiology, Immunology and Virology, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy
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DOI: 10.1128/CDLI.8.4.671-677.2001
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  • Table 1.

    Therapeutic and immunological characteristics of relevant clinical trials including IL-2 for the treatment of HIV-positive patients

    Investigators (reference)Baseline CD4 count (no. of cells/mm3)TreatmentCD4 increase [no. of cells/mm3 (%)] after:
    ARTaIL-2 treatment
    Simonelli et al. (58)200–500RTIs+60+256
    Davey et al. (13)>200RTIsND>200 (44), 0–200 (33)
    Emery et al. (19)100–500RTIs+153+368
    Levy et al. (36)250–550RTIs+55+564
    Davey et al. (14)200–500HAART+64+384
    Ruxrungtham et al. (55)≥350HAART+42+252
    Abrams et al.c≥300HAART+22+276
    • ↵a ART, antiretroviral therapy.

    • b ND, not determined.

    • ↵c Addendum Abstr. 40th Intersci. Conf. Antimicrob. Agents Chemother., abstr. L11, p. 24, 2000.

  • Table 2.

    Relevant results of clinical trials investigating immunological functions in IL-2 treated, HIV-positive patientsa

    ReferenceCytokine productionRecall antigen responseHIV-specific responseApoptosisThymic function
    De Paoli et al. (15)IL-2 ↑, IL-4 ↑
    Blanco et al. (5)Chemok. =
    Kelleher et al. (30)TT =, SS =Gag =, Pol =
    Levy et al. (36)PPD ↑CTL =
    Caggiari et al. (9)AICD =
    De Paoli et al. (submitted)TRECs =
    • ↵a Symbols and abbreviations: =, not modified; ↑, increased; AICD, activation-dependent cellular death; TT, tetanus toxoid; SS, streptokinase-streptodornase; PPD, purified protein derivative; Chemok., chemokine; CTL, cytotoxic T lymphocyte.

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Immunological Effects of Interleukin-2 Therapy in Human Immunodeficiency Virus-Positive Subjects
Paolo De Paoli
Clinical and Diagnostic Laboratory Immunology Jul 2001, 8 (4) 671-677; DOI: 10.1128/CDLI.8.4.671-677.2001

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Immunological Effects of Interleukin-2 Therapy in Human Immunodeficiency Virus-Positive Subjects
Paolo De Paoli
Clinical and Diagnostic Laboratory Immunology Jul 2001, 8 (4) 671-677; DOI: 10.1128/CDLI.8.4.671-677.2001
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  • Top
  • Article
    • IL-2 AND CD4 AND CD8 COUNTS
    • IL-2 AND CD4 AND CD8 SUBSETS IN PERIPHERAL BLOOD AND LT
    • IL-2 AND CHEMOKINE RECEPTOR EXPRESSION AND CHEMOKINE PRODUCTION
    • IL-2 AND CYTOKINE PRODUCTION
    • IL-2 AND T-CELL PROLIFERATION
    • IL-2 AND ANTIGEN-SPECIFIC IMMUNE RESPONSE
    • IL-2 AND CD4 LYMPHOCYTE APOPTOSIS
    • IL-2 AND THYMIC FUNCTION
    • IL-2 AND AUTOIMMUNITY
    • CONCLUSIONS
    • ACKNOWLEDGMENTS
    • REFERENCES
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