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Article

Decreased Superoxide Production, Degranulation, Tumor Necrosis Factor Alpha Secretion, and CD11b/CD18 Receptor Expression by Adherent Monocytes from Preterm Infants

David Kaufman, Laurie Kilpatrick, R. Guy Hudson, Donald E. Campbell, Ann Kaufman, Steven D. Douglas, Mary C. Harris
David Kaufman
Division of Neonatology,
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Laurie Kilpatrick
Division of Immunologic and Infectious Diseases, and
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R. Guy Hudson
Division of Neonatology,
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Donald E. Campbell
Division of Immunologic and Infectious Diseases, and
Clinical Immunology Laboratories, Department of Pediatrics, University of Pennsylvania School of Medicine, The Children’s Hospital of Philadelphia, Joseph Stokes Jr. Research Institute, Philadelphia, Pennsylvania 19104-4399
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Ann Kaufman
Division of Immunologic and Infectious Diseases, and
Clinical Immunology Laboratories, Department of Pediatrics, University of Pennsylvania School of Medicine, The Children’s Hospital of Philadelphia, Joseph Stokes Jr. Research Institute, Philadelphia, Pennsylvania 19104-4399
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Steven D. Douglas
Division of Immunologic and Infectious Diseases, and
Clinical Immunology Laboratories, Department of Pediatrics, University of Pennsylvania School of Medicine, The Children’s Hospital of Philadelphia, Joseph Stokes Jr. Research Institute, Philadelphia, Pennsylvania 19104-4399
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Mary C. Harris
Division of Neonatology,
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DOI: 10.1128/CDLI.6.4.525-529.1999
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ABSTRACT

Preterm infants have an increased incidence of infection, which is principally due to deficiencies in neonatal host defense mechanisms. Monocyte adherence is important in localizing cells at sites of infection and is associated with enhanced antimicrobial functions. We isolated cord blood monocytes from preterm and full-term infants to study their adhesion and immune functions, including superoxide (O2−) generation, degranulation, and cytokine secretion and their adhesion receptors. O2−production and degranulation were significantly diminished, by 28 and 37%, respectively, in adherent monocytes from preterm infants compared to full-term infants (P < 0.05); however, these differences were not seen in freshly isolated cells. We also observed a significant decrease of 35% in tumor necrosis factor alpha secretion by lipopolysaccharide-stimulated adherent monocytes from preterm infants compared to full-term infants (P < 0.05); however, this difference was not observed in interleukin-1β or interleukin-6 production by the monocytes. The cell surface expression of the CD11b/CD18 adhesion receptor subunits was significantly decreased (by 60 and 52%, respectively) in monocytes from preterm infants compared to full-term infants (P < 0.01). The cascade of the immune response to infection involves monocyte upregulation and adherence via CD11b/CD18 receptors followed by cell activation and the release of cytokines and bactericidal products. We speculate that monocyte adherence factors may be important in the modulation of immune responses in preterm infants.

  • Copyright © 1999 American Society for Microbiology
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Decreased Superoxide Production, Degranulation, Tumor Necrosis Factor Alpha Secretion, and CD11b/CD18 Receptor Expression by Adherent Monocytes from Preterm Infants
David Kaufman, Laurie Kilpatrick, R. Guy Hudson, Donald E. Campbell, Ann Kaufman, Steven D. Douglas, Mary C. Harris
Clinical and Diagnostic Laboratory Immunology Jul 1999, 6 (4) 525-529; DOI: 10.1128/CDLI.6.4.525-529.1999

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Decreased Superoxide Production, Degranulation, Tumor Necrosis Factor Alpha Secretion, and CD11b/CD18 Receptor Expression by Adherent Monocytes from Preterm Infants
David Kaufman, Laurie Kilpatrick, R. Guy Hudson, Donald E. Campbell, Ann Kaufman, Steven D. Douglas, Mary C. Harris
Clinical and Diagnostic Laboratory Immunology Jul 1999, 6 (4) 525-529; DOI: 10.1128/CDLI.6.4.525-529.1999
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