Increased Prevalence of Immunoglobulin A Deficiency in Patients with the Chromosome 22q11.2 Deletion Syndrome (DiGeorge Syndrome/Velocardiofacial Syndrome)

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Fig. 1.
IgA levels in patients with the chromosome 22q11.2 deletion syndrome. The solid lines designate the normal range (16).

Table 1.

Immunologic analyses of patients with the chromosome 22q11.2 deletion syndrome^a

Immunologic parameter	No. (%) of patients with IgA level/no. tested		P value
Immunologic parameter	<10 mg/dl	>10 mg/dl	P value
CD4, <900 cells/mm3	1/4 (25)	10/28 (36)	1.00
CD8, <400 cells/mm3	1/4 (25)	11/28 (39)	1.00
Phytohemagglutinin, <50% of control	0/4 (0)	6/28 (21)	0.57
IgG in serum, <553 mg/dl	0/4 (0)	3/28 (11)	1.00
IgM in serum, <35 mg/dl	0/4 (0)	2/28 (7)	1.00
Nonprotective tetanus or diphtheria titer^b	0/3 (0)	1/24 (4)	1.00

Table 2.

Relationship of IgA deficiency to other features associated with the chromosome 22q11.2 deletion syndrome^a

Phenotypic feature	No. (%) of patients with IgA level/no. tested		P value
Phenotypic feature	<10 mg/dl	>10 mg/dl	P value
Developmental delay	2/4 (50)	10/14 (71)	0.57
Cardiac defects	2/4 (50)	14/28 (50)	1.40
Hypocalcemia^b	1/4 (25)	13/27 (48)	0.61
Palatal abnormalities	3/4 (75)	13/28 (46)	0.60