Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My Cart

Main menu

  • Home
  • Articles
    • Archive
  • About the Journal
    • About CVI
    • For Librarians
    • For Advertisers
    • FAQ
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Clinical and Vaccine Immunology
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Archive
  • About the Journal
    • About CVI
    • For Librarians
    • For Advertisers
    • FAQ
Spotlight

Article of Significant Interest Selected from This Issue by the Editors

DOI: 10.1128/CVI.00158-17
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Mechanisms of Increased Susceptibility to Salmonella enterica Serovar Typhimurium Bacteremia in the Context of Malaria in African Children

Salmonella enterica serovar Typhimurium bacteremia is known to be associated with malaria in African children. To understand the immunological basis of this association, Nyirenda et al. (e00057-17) investigated bactericidal immunity to S. Typhimurium in children with acute and convalescent uncomplicated malaria and in controls. They found that Plasmodium falciparum infection reduced serum bactericidal activity to S. Typhimurium and was associated with reduced complement C3, irrespective of preexisting specific-IgG antibody titers. P. falciparum infection also reduced whole-blood bactericidal activity to S. Typhimurium and was associated with reduction of neutrophil respiratory burst. These findings provide new insights into the increase in susceptibility to S. Typhimurium bacteremia in children from settings of malaria endemicity.

Figure1
  • Open in new tab
  • Download powerpoint

P. falciparum infection compromises bactericidal immunity to S. Typhimurium (STm).

Virus-Like Particle Vaccine Platform That Mimics the Immature Form of Alphavirus

Urakami et al. (e00090-17) developed a novel vaccine platform, which is composed of an alphavirus virus-like particle (VLP) and any inserted epitope of choice. Robust immunogenicity against a target protein or pathogen was achieved through the dense and symmetrical display of 480 copies of the epitope. Furthermore, modification of the VLP by mimicking the immature form of an alphavirus enhanced immunogenicity. As proof of concept, effective immunogenicity and protection were achieved by employing the malaria circumsporozoite protein as the epitope inserted into the alphavirus VLP. This study supports the use of this novel platform as a blueprint for vaccine development against other pathogens and diseases.

Figure2
  • Open in new tab
  • Download powerpoint

Malaria epitope NANP-inserted VLPs.

Accurate and Rapid Distinction between Acute Infections Caused by Bacteria or Virus

Human neutrophil lipocalin (HNL) is released from blood neutrophils upon stimulation. The release is highly increased by blood neutrophils obtained from patients with bacterial infections as opposed to neutrophils obtained from patients with viral causes of their infection. Venge et al. (e00064-17) have invented a whole-blood format of activation of neutrophils that results in the accurate distinction between the causes of infections within a few minutes. The diagnostic accuracy of the HNL assay was shown to be superior to any other known biomarker, such as C-reactive protein (CRP), procalcitonin (PCT), and white blood cell counts, and the format lends itself to the development of rapid point-of-care assays.

Figure3
  • Open in new tab
  • Download powerpoint

Diagnostic accuracy of CRP and the HNL assay in the distinction between bacterial or viral causes in patients with infectious symptoms of the respiratory tract.

  • Copyright © 2017 American Society for Microbiology.

All Rights Reserved .

PreviousNext
Back to top
Download PDF
Citation Tools
Article of Significant Interest Selected from This Issue by the Editors
Clinical and Vaccine Immunology Jul 2017, 24 (7) e00158-17; DOI: 10.1128/CVI.00158-17

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Print

Email

Thank you for sharing this Clinical and Vaccine Immunology article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Article of Significant Interest Selected from This Issue by the Editors
(Your Name) has forwarded a page to you from Clinical and Vaccine Immunology
(Your Name) thought you would be interested in this article in Clinical and Vaccine Immunology.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Article of Significant Interest Selected from This Issue by the Editors
Clinical and Vaccine Immunology Jul 2017, 24 (7) e00158-17; DOI: 10.1128/CVI.00158-17
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Top
  • Article
    • Mechanisms of Increased Susceptibility to Salmonella enterica Serovar Typhimurium Bacteremia in the Context of Malaria in African Children
    • Virus-Like Particle Vaccine Platform That Mimics the Immature Form of Alphavirus
    • Accurate and Rapid Distinction between Acute Infections Caused by Bacteria or Virus
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

Cited By...

About

  • About CVI
  • For Librarians
  • For Advertisers
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • Submit a Manuscript to mSphere

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 1556-6811; Online ISSN: 1556-679X