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Vaccines for Nontypeable Haemophilus influenzae: the Future Is Now

Timothy F. Murphy
C. J. Papasian, Editor
Timothy F. Murphy
Division of Infectious Diseases, Department of Medicine, Clinical and Translational Research Center, Department of Microbiology and Immunology, University at Buffalo, State University of New York, Buffalo, New York, USA
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C. J. Papasian
Roles: Editor
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DOI: 10.1128/CVI.00089-15
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Tables

  • TABLE 1

    Rationale for vaccine development for nontypeable Haemophilus influenzae

    InfectionPopulation to vaccinateWhat vaccine will accomplish
    Otitis mediaAll children beginning at 2 mo of agePrevention of:
        Acute otitis media
        Recurrent otitis media
        Chronic otitis media
        Otitis media with effusion related to bacterial biofilm formation
        Chronic suppurative otitis media
    Reductions in:
        Excess antibiotic use
        Health care costs
    Exacerbation of COPDAdults with COPDPrevention of:
        Acute exacerbations of COPD
        Chronic airway colonization
    Reductions in:
        Excess antibiotic use
        Health care costs
  • TABLE 2

    Haemophilus influenzae vaccine antigens under study

    AntigenMolecular mass (kDa)FunctionReference(s)
    Haemophilus adhesin protein (Hap)∼155Adhesin71–73
    HMW1, HMW2120–125Adhesins74–76
    H. influenzae adhesin (Hia)∼115Adhesin77, 78
    D15 protein∼80Predicted nucleotidyltransferase79, 80
    HtrA∼46Heat shock protein81
    P2 porin36–42Porin protein65, 66, 82
    Lipoprotein D∼42Glycerophosphodiester phosphodiesterase45, 56, 83
    P5 fimbrin27–35Adhesin, OMP A-like protein51, 84–86
    P4 protein∼30Acid phosphatase87–89
    Protein F∼30Adhesin, ABC transporter90–92
    OMP 26∼26Skp family of translocation proteins85, 93–95
    P6 protein∼16Peptidoglycan-associated lipoprotein96–102
    Protein E∼16Adhesin, binds IgD103–106
    PilA (type IV pilus)∼14Adhesin, transformation51, 107–109
    Detoxified lipooligosaccharide3–5Endotoxin110–113
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Vaccines for Nontypeable Haemophilus influenzae: the Future Is Now
Timothy F. Murphy
Clinical and Vaccine Immunology Apr 2015, 22 (5) 459-466; DOI: 10.1128/CVI.00089-15

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Vaccines for Nontypeable Haemophilus influenzae: the Future Is Now
Timothy F. Murphy
Clinical and Vaccine Immunology Apr 2015, 22 (5) 459-466; DOI: 10.1128/CVI.00089-15
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  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • RATIONALE FOR A VACCINE FOR NONTYPEABLE H. INFLUENZAE
    • OTITIS MEDIA
    • INFECTIONS IN COPD
    • VACCINES TO REDUCE ANTIMICROBIAL RESISTANCE
    • FEASIBILITY OF A VACCINE FOR NONTYPEABLE H. INFLUENZAE
    • CORRELATES OF PROTECTION
    • APPROACH TO VACCINE DEVELOPMENT FOR NONTYPEABLE H. INFLUENZAE
    • CANDIDATE VACCINE ANTIGENS
    • SUMMARY AND FUTURE DIRECTIONS
    • ACKNOWLEDGMENT
    • REFERENCES
  • Figures & Data
  • Info & Metrics
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