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Vaccines

Efficacy of Human Papillomavirus 16 and 18 (HPV-16/18) AS04-Adjuvanted Vaccine against Cervical Infection and Precancer in Young Women: Final Event-Driven Analysis of the Randomized, Double-Blind PATRICIA Trial

Dan Apter, Cosette M. Wheeler, Jorma Paavonen, Xavier Castellsagué, Suzanne M. Garland, S. Rachel Skinner, Paulo Naud, Jorge Salmerón, Song-Nan Chow, Henry C. Kitchener, Julio C. Teixeira, Unnop Jaisamrarn, Genara Limson, Anne Szarewski, Barbara Romanowski, Fred Y. Aoki, Tino F. Schwarz, Willy A. J. Poppe, F. Xavier Bosch, Adrian Mindel, Philippe de Sutter, Karin Hardt, Toufik Zahaf, Dominique Descamps, Frank Struyf, Matti Lehtinen, Gary Dubin
S. A. Plotkin, Editor
Dan Apter
aFamily Federation of Finland, Sexual Health Clinic, Helsinki, Finland
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Cosette M. Wheeler
bDepartments of Pathology and Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
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Jorma Paavonen
cDepartment of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland
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Xavier Castellsagué
dCancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, Biomedical Research Centre Network for Epidemiology and Public Health (CIBER-ESP), L'Hospitalet de Llobregat, Catalonia, Spain
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Suzanne M. Garland
eMicrobiology and Infectious Diseases Department, Royal Women's Hospital and Department of Obstetrics and Gynaecology, University of Melbourne, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia
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S. Rachel Skinner
fVaccine Trials Group, Telethon Institute for Child Health Research, Perth, Western Australia, and Sydney University Discipline of Paediatrics and Child Health, Children's Hospital at Westmead, Sydney, New South Wales, Australia
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Paulo Naud
gUniversity Federal of Rio Grande do Sul, Hospital de Clínica de Porto Alegre, Porto Alegre, Brazil
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Jorge Salmerón
hUnidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Morelos, Mexico
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Song-Nan Chow
iDepartment of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei, Taiwan
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Henry C. Kitchener
jManchester Academic Health Science Centre, Central Manchester University Hospitals NHS Foundation Trust, St Mary's Hospital, Manchester, United Kingdom
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Julio C. Teixeira
kUniversity of Campinas, Campinas, Brazil
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Unnop Jaisamrarn
lChulalongkorn University, Department of Obstetrics and Gynaecology, Faculty of Medicine, Bangkok, Thailand
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Genara Limson
mUniversity of the Philippines, College of Medicine, Philippine General Hospital, Makati Medical Centre, Makati City, Philippines
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Anne Szarewski
nCentre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, United Kingdom
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Barbara Romanowski
oUniversity of Alberta, Edmonton, Alberta, Canada
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Fred Y. Aoki
pUniversity of Manitoba, Winnipeg, Manitoba, Canada
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Tino F. Schwarz
qCentral Laboratory and Vaccination Centre, Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg, Wuerzburg, Germany
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Willy A. J. Poppe
rDepartment of Gynaecology, University Hospital KU Leuven Gasthuisberg, Leuven, Belgium
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F. Xavier Bosch
sCancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, Network on Cooperative Cancer Research (RTICC), L'Hospitalet de Llobregat, Catalonia, Spain
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Adrian Mindel
tCentre for AIDS Programme of Research in South Africa, Durban, South Africa
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Philippe de Sutter
uAfdelingshoofd Gynaecologie-Oncologie, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
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Karin Hardt
vGSK Vaccines, Wavre, Belgium
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Toufik Zahaf
vGSK Vaccines, Wavre, Belgium
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Dominique Descamps
vGSK Vaccines, Wavre, Belgium
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Frank Struyf
vGSK Vaccines, Wavre, Belgium
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Matti Lehtinen
wUniversity of Tampere, School of Public Health, Tampere, Finland
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Gary Dubin
xGSK Vaccines, King of Prussia, Pennsylvania, USA
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S. A. Plotkin
Roles: Editor
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DOI: 10.1128/CVI.00591-14
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Article Information

DOI 
https://doi.org/10.1128/CVI.00591-14
PubMed 
25651922

Published By 
American Society for Microbiology Journals
History 
  • Received September 5, 2014
  • Returned for modification September 24, 2014
  • Accepted December 23, 2014
  • Published online March 26, 2015.

Copyright & Usage 
Copyright © 2015, American Society for Microbiology. All Rights Reserved. The authors have paid a fee to allow immediate free access to this article.
Editors and / or Reviewers 
  • S. A. Plotkin, Editor

Article Versions

  • Accepted Manuscript version (February 04, 2015).
  • You are viewing the most recent version of this article.

Author Information

  1. Dan Aptera,
  2. Cosette M. Wheelerb,
  3. Jorma Paavonenc,
  4. Xavier Castellsaguéd,
  5. Suzanne M. Garlande,
  6. S. Rachel Skinnerf,
  7. Paulo Naudg,
  8. Jorge Salmerónh,
  9. Song-Nan Chowi,
  10. Henry C. Kitchenerj,
  11. Julio C. Teixeirak,
  12. Unnop Jaisamrarnl,
  13. Genara Limsonm,
  14. Anne Szarewskin†,
  15. Barbara Romanowskio,
  16. Fred Y. Aokip,
  17. Tino F. Schwarzq,
  18. Willy A. J. Popper,
  19. F. Xavier Boschs,
  20. Adrian Mindelt,
  21. Philippe de Sutteru,
  22. Karin Hardtv,
  23. Toufik Zahafv,
  24. Dominique Descampsv,
  25. Frank Struyfv,
  26. Matti Lehtinenw and
  27. Gary Dubinx
  28. for the HPV PATRICIA Study Group
  1. aFamily Federation of Finland, Sexual Health Clinic, Helsinki, Finland
  2. bDepartments of Pathology and Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
  3. cDepartment of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland
  4. dCancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, Biomedical Research Centre Network for Epidemiology and Public Health (CIBER-ESP), L'Hospitalet de Llobregat, Catalonia, Spain
  5. eMicrobiology and Infectious Diseases Department, Royal Women's Hospital and Department of Obstetrics and Gynaecology, University of Melbourne, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia
  6. fVaccine Trials Group, Telethon Institute for Child Health Research, Perth, Western Australia, and Sydney University Discipline of Paediatrics and Child Health, Children's Hospital at Westmead, Sydney, New South Wales, Australia
  7. gUniversity Federal of Rio Grande do Sul, Hospital de Clínica de Porto Alegre, Porto Alegre, Brazil
  8. hUnidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Morelos, Mexico
  9. iDepartment of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei, Taiwan
  10. jManchester Academic Health Science Centre, Central Manchester University Hospitals NHS Foundation Trust, St Mary's Hospital, Manchester, United Kingdom
  11. kUniversity of Campinas, Campinas, Brazil
  12. lChulalongkorn University, Department of Obstetrics and Gynaecology, Faculty of Medicine, Bangkok, Thailand
  13. mUniversity of the Philippines, College of Medicine, Philippine General Hospital, Makati Medical Centre, Makati City, Philippines
  14. nCentre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, United Kingdom
  15. oUniversity of Alberta, Edmonton, Alberta, Canada
  16. pUniversity of Manitoba, Winnipeg, Manitoba, Canada
  17. qCentral Laboratory and Vaccination Centre, Stiftung Juliusspital, Academic Teaching Hospital of the University of Wuerzburg, Wuerzburg, Germany
  18. rDepartment of Gynaecology, University Hospital KU Leuven Gasthuisberg, Leuven, Belgium
  19. sCancer Epidemiology Research Program, Institut Català d'Oncologia (ICO), IDIBELL, Network on Cooperative Cancer Research (RTICC), L'Hospitalet de Llobregat, Catalonia, Spain
  20. tCentre for AIDS Programme of Research in South Africa, Durban, South Africa
  21. uAfdelingshoofd Gynaecologie-Oncologie, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
  22. vGSK Vaccines, Wavre, Belgium
  23. wUniversity of Tampere, School of Public Health, Tampere, Finland
  24. xGSK Vaccines, King of Prussia, Pennsylvania, USA
  • Address correspondence to Dan Apter, dan.apter{at}vaestoliitto.fi.
  • ↵† Deceased.

  • Citation Apter D, Wheeler CM, Paavonen J, Castellsagué X, Garland SM, Skinner SR, Naud P, Salmerón J, Chow S-N, Kitchener HC, Teixeira JC, Jaisamrarn U, Limson G, Szarewski A, Romanowski B, Aoki FY, Schwarz TF, Poppe WAJ, Bosch FX, Mindel A, de Sutter P, Hardt K, Zahaf T, Descamps D, Struyf F, Lehtinen M, Dubin G, HPV PATRICIA Study Group. 2015. Efficacy of human papillomavirus 16 and 18 (HPV-16/18) AS04-adjuvanted vaccine against cervical infection and precancer in young women: final event-driven analysis of the randomized, double-blind PATRICIA trial. Clin Vaccine Immunol 22:361–373. doi:10.1128/CVI.00591-14.

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Efficacy of Human Papillomavirus 16 and 18 (HPV-16/18) AS04-Adjuvanted Vaccine against Cervical Infection and Precancer in Young Women: Final Event-Driven Analysis of the Randomized, Double-Blind PATRICIA Trial
Dan Apter, Cosette M. Wheeler, Jorma Paavonen, Xavier Castellsagué, Suzanne M. Garland, S. Rachel Skinner, Paulo Naud, Jorge Salmerón, Song-Nan Chow, Henry C. Kitchener, Julio C. Teixeira, Unnop Jaisamrarn, Genara Limson, Anne Szarewski, Barbara Romanowski, Fred Y. Aoki, Tino F. Schwarz, Willy A. J. Poppe, F. Xavier Bosch, Adrian Mindel, Philippe de Sutter, Karin Hardt, Toufik Zahaf, Dominique Descamps, Frank Struyf, Matti Lehtinen, Gary Dubin for the HPV PATRICIA Study Group
Clinical and Vaccine Immunology Mar 2015, 22 (4) 361-373; DOI: 10.1128/CVI.00591-14

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Efficacy of Human Papillomavirus 16 and 18 (HPV-16/18) AS04-Adjuvanted Vaccine against Cervical Infection and Precancer in Young Women: Final Event-Driven Analysis of the Randomized, Double-Blind PATRICIA Trial
Dan Apter, Cosette M. Wheeler, Jorma Paavonen, Xavier Castellsagué, Suzanne M. Garland, S. Rachel Skinner, Paulo Naud, Jorge Salmerón, Song-Nan Chow, Henry C. Kitchener, Julio C. Teixeira, Unnop Jaisamrarn, Genara Limson, Anne Szarewski, Barbara Romanowski, Fred Y. Aoki, Tino F. Schwarz, Willy A. J. Poppe, F. Xavier Bosch, Adrian Mindel, Philippe de Sutter, Karin Hardt, Toufik Zahaf, Dominique Descamps, Frank Struyf, Matti Lehtinen, Gary Dubin for the HPV PATRICIA Study Group
Clinical and Vaccine Immunology Mar 2015, 22 (4) 361-373; DOI: 10.1128/CVI.00591-14
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