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Diagnostic Laboratory Immunology

Evaluation of Bio-Rad Geenius HIV-1 and -2 Assay as a Confirmatory Assay for Detection of HIV-1 and -2 Antibodies

Anne Hawthorne Hallen, Agneta Samuelson, Margareta Nordin, Jan Albert, Gordana Bogdanovic
R. L. Hodinka, Editor
Anne Hawthorne Hallen
aDepartment of Clinical Microbiology, Vastmanland Hospital, Västerås, Sweden
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Agneta Samuelson
bDepartment of Clinical Microbiology, Karolinska University Hospital Stockholm, Sweden
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Margareta Nordin
bDepartment of Clinical Microbiology, Karolinska University Hospital Stockholm, Sweden
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Jan Albert
bDepartment of Clinical Microbiology, Karolinska University Hospital Stockholm, Sweden
cDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
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Gordana Bogdanovic
bDepartment of Clinical Microbiology, Karolinska University Hospital Stockholm, Sweden
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R. L. Hodinka
Roles: Editor
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DOI: 10.1128/CVI.00153-14
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  • TABLE 1

    Comparison of results from the RIBA and Geenius HIV assays

    Sample type and HIV statusnNo. with each RIBA resultNo. with each Geenius result
    NegativeIndeterminatePositiveNegativeIndeterminatePositive
    Retrospective clinical samplesa
        HIV-1 positive2300230023
        HIV-2 positive1001001
        HIV-1 and HIV-2 positive1001001
        HIV negative2525002410
    Acute HIV infectionb5050212
    Acute HIV seroconversion panelb
        1:e sample10910802
        2:e sample10055406
    Prospective clinical samples793534137042
    Total15469147175277
    • ↵a HIV status for the retrospectively analyzed positive samples was based on results from follow-up testing confirming HIV infection with RIBA or HIV RNA/DNA. HIV status for the retrospectively analyzed negative samples was based on negative results for both HIV antigen assay tests and follow-up tests. These include samples from 10 blood donors.

    • ↵b Acute-phase HIV infection status was based on indeterminate or negative RIBA results, a positive HIV antigen assay result, and documented HIV seroconversion in follow-up samples.

  • TABLE 2

    Results for seroconversion sample panel

    Patient no.Sample no.Date (daysb)Sample resulta
    HIV antigenNTRIBAGeenius
    110PosPosNegNeg
    2+4PosIndPos
    210PosPosNegNeg
    2+7NDPosPos
    310PosPosNegNeg
    2+12PosPosPos
    410PosPosNegNeg
    2+24PosPosPos
    510PosPosNegPos
    2+14NegPosPos
    610PosPosNegNeg
    2+4PosPosNeg
    710PosPosNegNeg
    2+11PosIndNeg
    810PosPosNegNeg
    2+7PosIndNeg
    910PosPosNegNeg
    2+8PosIndNeg
    1010PosPosIndPos
    2+41NDIndPos
    • ↵a NT, neutralization test for confirmation of HIV antigen; Neg, negative; Ind, indeterminate; Pos, positive; ND, not done.

    • ↵b Number of days between first and second samples.

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Evaluation of Bio-Rad Geenius HIV-1 and -2 Assay as a Confirmatory Assay for Detection of HIV-1 and -2 Antibodies
Anne Hawthorne Hallen, Agneta Samuelson, Margareta Nordin, Jan Albert, Gordana Bogdanovic
Clinical and Vaccine Immunology Jul 2014, 21 (8) 1192-1194; DOI: 10.1128/CVI.00153-14

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Evaluation of Bio-Rad Geenius HIV-1 and -2 Assay as a Confirmatory Assay for Detection of HIV-1 and -2 Antibodies
Anne Hawthorne Hallen, Agneta Samuelson, Margareta Nordin, Jan Albert, Gordana Bogdanovic
Clinical and Vaccine Immunology Jul 2014, 21 (8) 1192-1194; DOI: 10.1128/CVI.00153-14
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