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Diagnostic Laboratory Immunology

Mycobacterium avium subsp. paratuberculosis Antibody Response, Fecal Shedding, and Antibody Cross-Reactivity to Mycobacterium bovis in M. avium subsp. paratuberculosis-Infected Cattle Herds Vaccinated against Johne's Disease

Deepanker Tewari, Ernest Hovingh, Rick Linscott, Edmond Martel, John Lawrence, David Wolfgang, David Griswold
W. R. Waters, Editor
Deepanker Tewari
aMicrobiology and Molecular Biology Section, Pennsylvania Veterinary Laboratory, Pennsylvania Department of Agriculture, Harrisburg, Pennsylvania, USA
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Ernest Hovingh
bField Investigation, Veterinary Biomedical Department, Pennsylvania State University, State College, Pennsylvania, USA
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Rick Linscott
cLivestock and Poultry Diagnostics, IDEXX Laboratories, Westbrook, Maine, USA
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Edmond Martel
cLivestock and Poultry Diagnostics, IDEXX Laboratories, Westbrook, Maine, USA
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John Lawrence
cLivestock and Poultry Diagnostics, IDEXX Laboratories, Westbrook, Maine, USA
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David Wolfgang
bField Investigation, Veterinary Biomedical Department, Pennsylvania State University, State College, Pennsylvania, USA
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David Griswold
dBureau of Animal Health, Pennsylvania Department of Agriculture, Harrisburg, Pennsylvania, USA
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W. R. Waters
Roles: Editor
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DOI: 10.1128/CVI.00032-14
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    FIG 1

    Serological responses to Johne's disease vaccination. (A) Line plot showing the trend of serum S/P ratios (y axis) tested annually during the 5-year study period (years 1 to 5), from >2 years to 7 years of age (x axis), for selected animals (n = 5; animals A, B, C, D, and F). (B) Scatter plot showing the trend of serum S/P ratios (y axis, with maximum capped values of 1.2) tested during the 5-year study period (years 1 to 5), from >2 years to 7 years of age (x axis), for selected animals (n = 9; animals A to I).

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  • TABLE 1

    Mycobacterium avium subsp. paratuberculosis annual antibody responses and fecal shedding in M. avium subsp. paratuberculosis-infected cattle herds receiving M. avium subsp. paratuberculosis vaccination with management changes (herd A) or without management changes (herd B)

    Herd and yrNo. in herdaNo. (%)b
    VaccinatedTotalVaccinatedELISA positive
    ELISA positiveFecal culture positiveELISA positiveFecal culture positiveFecal culture positiveVaccinated fecal culture positive
    A
        200411674 (63.7)49 (42.2)7 (6)47 (63.7)020
        2005116105 (90.5)74 (63.7)1 (0.8)73 (69.5)000
        2006115110 (95.6)78 (67.8)3 (2.4)78 (70.9)1 (0.9)00
        2007122122 (100)40 (32.7)2c/3 (2.4)40 (32.7)2c/3 (2.4)22
        2008125125 (100)65 (52.0)3c/4 (3.2)65 (52)3c/4 (3.2)22
        200912894 (73.4)49 (38.2)2c/3 (2.3)49 (52.2)1 (1)00
        201012866 (51.5)35 (27.3)1 (0.7)34 (51.5)000
    B
        20044303 (6.6)10 (23.2)0030
        2005452 (4.4)7 (15.5)8c/11 (24.4)2 (100)1 (50)31
        20065230 (57.6)30 (57.6)8c/11 (21.1)25 (83.3)4c/5 (16.6)93
        20076149 (80.3)27 (44.2)3c/4 (7.2)26 (53.0)2c/3 (6.1)33
        20085552 (94.5)33 (60)3c/5 (9.0)32 (61.5)3c/4 (7.6)42
        20095251 (98)32 (61.5)5c/6 (11.5)31 (60.7)5c/6 (11.7)64
        20105049 (98)25 (50)2 (4.0)25 (51.0)2 (4.0)21
    • ↵a The numbers of animals >24 months of age are indicated for each study year.

    • ↵b Total and vaccinated ELISA- and M. avium subsp. paratuberculosis fecal culture-positive animals are indicated as ELISA positive and fecal culture positive, respectively. Animals that were ELISA positive and were M. avium subsp. paratuberculosis fecal culture positive in the total and vaccinated groups are indicated as fecal culture positive and vaccinated fecal culture positive, respectively, under ELISA positive.

    • ↵c New infections for each year are indicated, showing totals for new infections and total positive results.

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Mycobacterium avium subsp. paratuberculosis Antibody Response, Fecal Shedding, and Antibody Cross-Reactivity to Mycobacterium bovis in M. avium subsp. paratuberculosis-Infected Cattle Herds Vaccinated against Johne's Disease
Deepanker Tewari, Ernest Hovingh, Rick Linscott, Edmond Martel, John Lawrence, David Wolfgang, David Griswold
Clinical and Vaccine Immunology May 2014, 21 (5) 698-703; DOI: 10.1128/CVI.00032-14

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Mycobacterium avium subsp. paratuberculosis Antibody Response, Fecal Shedding, and Antibody Cross-Reactivity to Mycobacterium bovis in M. avium subsp. paratuberculosis-Infected Cattle Herds Vaccinated against Johne's Disease
Deepanker Tewari, Ernest Hovingh, Rick Linscott, Edmond Martel, John Lawrence, David Wolfgang, David Griswold
Clinical and Vaccine Immunology May 2014, 21 (5) 698-703; DOI: 10.1128/CVI.00032-14
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