Impaired Lymphocyte Reactivity Measured by Immune Function Testing in Untransplanted Patients with Cirrhosis

DOI: 10.1128/CVI.00595-12

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Fig 1
Cumulative analysis of mitogen-inducible CD4⁺ T cell ATP values as measured by the IFT assay. Values are displayed as boxes representing interquartile (25th to 75th percentile) groups. The horizontal bar within each box represents the median value, the plus sign (+) represents the mean, and whiskers represent the full range of values in each patient group.

Table 1

Demographic and clinical characteristics

Variable	Value for group				P value^a
Variable	Chronic HCV, no cirrhosis (n = 35)	Chronic HCV, cirrhosis (n = 40)	Alcohol/NASH cirrhosis (n = 21)	Uninfected, no cirrhosis (n = 22)	P value^a
Age, yr (mean ± SD)	57.0 ± 8.8	60.8 ± 4.7	60.0 ± 6.2	58.4 ± 7.6	0.06^c
Gender, no. (%)
Female	2 (5.7)	1 (2.5)	0 (0.0)	1 (4.5)	0.76^b
Male	33 (94.3)	39 (97.5)	21 (100.0)	21 (95.5)
Ethnicity, no. (%)
Caucasian	19 (54.3)	26 (65.0)	17 (81.0)	15 (68.2)	0.49
Black	10 (28.6)	8 (20.0)	1 (4.8)	4 (18.2)
Other	6 (17.1)	6 (15.0)	3 (14.3)	3 (13.6)
Hepatocellular carcinoma, no. (%)
Yes	0 (0.0)	7 (17.9)	3 (14.3)	0 (0.0)	0.006^b
No	35 (100.0)	32 (82.1)	18 (85.7)	22 (100.0)
BMI (mean ± SD)	27.2 ± 4.6	28.4 ± 4.36	29.2 ± 6.3	29.3+-5.2	0.40^c
Alcohol, no. (%)
Yes	2 (5.9)	16 (41.0)	17 (81.0)	5 (22.7)	<0.0001
No	32 (94.1)	23 (59.0)	4 (19.0)	17 (77.3)
ATP (ng/ml), median (IQR)	432 (366.2–552.1)	256.7 (176.5–425.5)	392.1 (280.3–519.4)	456.3 (301.6–726.8)	0.0001^c
ALT (U/liter), median (IQR)	40 (26–64)	67 (39–96.5)	23 (15–35)	27 (20–52)	<0.0001^c

↵a P values were calculated from the chi-square test for category variables and ANOVA for continuous variables unless otherwise indicated.
↵b P values were calculated from Fisher's exact test.
↵c The variable was rank transformed.

Table 2

Association between patient group and CD4⁺ T cell reactivity

Variable	Value for group		Relative risk (95% CI)	P value
Variable	ATP ≤ 226 (n = 21)	ATP > 226 (n = 97)	Relative risk (95% CI)	P value
Cirrhosis, no. (%)
Yes	18 (29.5)	43 (70.5)	7.5 (2.1–27.3)	0.002
No	3 (5.3)	54 (94.7)	Reference
HCV/cirrhosis group, no. (%)
Chronic HCV and cirrhosis	13 (32.5)	27 (67.5)	4.8 (1.0–23.8)	0.05
Alcohol/NASH cirrhosis	5 (23.8)	16 (76.2)	3.1 (0.5–18.3)	0.21
Chronic HCV, no cirrhosis	1 (2.9)	34 (97.1)	0.3 (0.03–3.5)	0.33
Uninfected, no cirrhosis	2 (9.1)	20 (90.9)	Reference