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CLINICAL LABORATORY IMMUNOLOGY

Identification of Anti-Alpha Toxin Monoclonal Antibodies That Reduce the Severity of Staphylococcus aureus Dermonecrosis and Exhibit a Correlation between Affinity and Potency

C. Tkaczyk, L. Hua, R. Varkey, Y. Shi, L. Dettinger, R. Woods, A. Barnes, R. S. MacGill, S. Wilson, P. Chowdhury, C. K. Stover, B. R. Sellman
C. Tkaczyk
Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, USA
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L. Hua
Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, USA
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R. Varkey
Antibody Discovery and Protein Engineering, MedImmune, LLC, Gaithersburg, Maryland, USA
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Y. Shi
Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, USA
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L. Dettinger
Antibody Discovery and Protein Engineering, MedImmune, LLC, Gaithersburg, Maryland, USA
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R. Woods
Antibody Discovery and Protein Engineering, MedImmune, LLC, Gaithersburg, Maryland, USA
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A. Barnes
Antibody Discovery and Protein Engineering, MedImmune, LLC, Gaithersburg, Maryland, USA
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R. S. MacGill
Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, USA
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S. Wilson
Antibody Discovery and Protein Engineering, MedImmune, LLC, Gaithersburg, Maryland, USA
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P. Chowdhury
Antibody Discovery and Protein Engineering, MedImmune, LLC, Gaithersburg, Maryland, USA
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C. K. Stover
Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, USA
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B. R. Sellman
Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, USA
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DOI: 10.1128/CVI.05589-11
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Article Information

DOI 
https://doi.org/10.1128/CVI.05589-11
PubMed 
22237895

Published By 
American Society for Microbiology Journals
History 
  • Received November 3, 2011
  • Returned for modification December 8, 2011
  • Accepted December 27, 2011
  • Published online February 27, 2012.

Copyright & Usage 
Copyright © 2012, American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (January 11, 2012).
  • You are viewing the most recent version of this article.

Author Information

  1. C. Tkaczyka,
  2. L. Huaa,
  3. R. Varkeyb,
  4. Y. Shia,
  5. L. Dettingerb,
  6. R. Woodsb,
  7. A. Barnesb,
  8. R. S. MacGilla,
  9. S. Wilsonb,
  10. P. Chowdhuryb,
  11. C. K. Stovera and
  12. B. R. Sellmana
  1. aDepartment of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, USA
  2. bAntibody Discovery and Protein Engineering, MedImmune, LLC, Gaithersburg, Maryland, USA
  • Address correspondence to B. R. Sellman, sellmanb{at}medimmune.com.
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Identification of Anti-Alpha Toxin Monoclonal Antibodies That Reduce the Severity of Staphylococcus aureus Dermonecrosis and Exhibit a Correlation between Affinity and Potency
C. Tkaczyk, L. Hua, R. Varkey, Y. Shi, L. Dettinger, R. Woods, A. Barnes, R. S. MacGill, S. Wilson, P. Chowdhury, C. K. Stover, B. R. Sellman
Clinical and Vaccine Immunology Feb 2012, 19 (3) 377-385; DOI: 10.1128/CVI.05589-11

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Identification of Anti-Alpha Toxin Monoclonal Antibodies That Reduce the Severity of Staphylococcus aureus Dermonecrosis and Exhibit a Correlation between Affinity and Potency
C. Tkaczyk, L. Hua, R. Varkey, Y. Shi, L. Dettinger, R. Woods, A. Barnes, R. S. MacGill, S. Wilson, P. Chowdhury, C. K. Stover, B. R. Sellman
Clinical and Vaccine Immunology Feb 2012, 19 (3) 377-385; DOI: 10.1128/CVI.05589-11
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