DOI: 10.1128/CVI.00405-12
Article Figures & Data
Tables
- Table 1
Observed IFN-γ test sensitivity and specificity values
Test resulta VL alpacas (n = 55) TB-free alpacas (n = 257) n/55 % sensitivity 95% CI n/257 % specificity 95% CI PPD+ 35 63.6 50.9–76.3 28 89.1 85.3–92.9 EC+ 27 49.1 35.9–62.3 26 89.9 86.2–93.6 EC+ PPD− 8 14.5 5.2–23.8 21 91.8 88.4–95.2 PPD+ EC+ 19 34.6 22.0–47.2 5 98.1 96.4–99.8 PPD+ or EC+ 44 80.0 69.4–90.6 49 80.9 76.1–85.7 ↵a PPD, PPDB − PPDA; EC, ESAT6-CFP10 peptide cocktail.
- Table 2
Increasing the IFN-γ test specificity values
Test resulta VL alpacas (n = 55) TB-free alpacas (n = 257) n/55 % sensitivity 95% CI n/257 % specificity 95% CI PPD+ 16 29.1 17.1–41.1 8 96.9 94.8–99.0 EC+ 16 29.1 17.1–41.1 8 96.9 94.8–99.0 EC+ PPD− 7 12.7 3.9–21.5 8 96.9 94.8–99.0 PPD+ EC+ 9 16.4 6.6–26.1 0 100.0 98.6–100 PPD+ or EC+ 23 41.8 28.8–54.8 16 93.8 90.9–96.7 ↵a PPD, PPDB − PPDA; EC, ESAT6-CFP10 peptide cocktail.
- Table 3
Antibody test sensitivity and specificity values
Test VL alpacas TB-free alpacas n/total % sensitivity 95% CI n/total % specificity 95% CI Stat-Pak 35/52 67.3 54.5–80.8 8/306 97.4 95.6–99.2 DPP 30/52 57.7 44.3–71.1 10/306 96.7 94.1–98.4 Idexx 36/52 69.2 56.7–81.7 8/306 97.4 95.6–99.2 Enferplex 32/48 66.7 53.4–80.0 8/257 96.9 94.8–99.0 - Table 4
IFN-γ and antibody test combinations and sensitivity and specificity valuesa
Test combination VL alpacas (n = 48) TB-free alpacas (n = 257) n/48 % sensitivity 95% CI n/257 % specificity 95% CI IFN-γ + Stat-Pak 45 93.8 87.0–100 52 79.2 74.2–84.2 IFN-γ + Idexx 44 91.7 83.9–99.5 55 78.6 73.6–83.6 IFN-γ + DPP 44 91.7 83.9–99.5 58 77.4 72.3–82.5 IFN-γ + Enferplex 45 93.8 87–100 58 77.4 72.3–82.5 IFN-γ + Stat-Pak + Idexx 48 100 92.6–100 57 77.8 72.7–82.9 IFN-γ + Stat-Pak + DPP 48 100 92.6–100 60 76.7 71.5–81.9 IFN-γ + Stat-Pak + Enferplex 47 97.9 93.8–100 60 76.7 71.5–81.9 IFN-γ + Idexx + DPP 45 93.8 87.0–100 62 75.9 70.0–81.2 IFN-γ + Idexx + Enferplex 44 91.7 83.9–99.5 62 75.9 70.0–81.2 IFN-γ + Enferplex + DPP 47 97.9 93.8–100 65 74.7 69.4–80 ↵a IFN-γ positive, PPDB-PPDA > 0.1 or EC-nil > 0.1.