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VACCINE RESEARCH

Immunogenicity of Inactivated Polio Vaccine with Concurrent Antiviral V-073 Administration in Mice

Diana Kouiavskaia, Marc S. Collett, Eugenia M. Dragunsky, Andrey Sarafanov, Konstantin M. Chumakov
Diana Kouiavskaia
Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland
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Marc S. Collett
ViroDefense, Inc., Rockville, Maryland
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Eugenia M. Dragunsky
Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland
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Andrey Sarafanov
Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland
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Konstantin M. Chumakov
Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland
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  • For correspondence: konstantin.chumakov@fda.hhs.gov
DOI: 10.1128/CVI.05147-11
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    Fig. 1.

    Pharmacokinetics of V-073 in mice (Cmax, ng/ml; AUC24, ng·h/ml).

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    Fig. 2.

    Schedules of immunization and antiviral treatment.

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    Fig. 3.

    Percentage of animals in which serum-neutralizing antibody response was elicited by IPV administered to untreated mice and mice administered vehicle or various doses of V-073 (1, 3, 10, and 30 mg/kg) at the time of primary vaccination (A) or booster immunization (B). The response was assessed on days 20 (before booster), 28 (7 days after booster), and 35 (14 days after booster).

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    Fig. 4.

    Serum-neutralizing (SN) antibody titers elicited by IPV in untreated mice (NT) and mice administered vehicle (V) or various doses of V-073 (1, 3, 10, and 30 mg/kg) at the time of primary vaccination (A) or booster immunization (B). Median titers are indicated by the solid line in each column, and geometric mean titer (GMT) values are provided below for each indicated group.

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Immunogenicity of Inactivated Polio Vaccine with Concurrent Antiviral V-073 Administration in Mice
Diana Kouiavskaia, Marc S. Collett, Eugenia M. Dragunsky, Andrey Sarafanov, Konstantin M. Chumakov
Clinical and Vaccine Immunology Aug 2011, 18 (8) 1387-1390; DOI: 10.1128/CVI.05147-11

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Immunogenicity of Inactivated Polio Vaccine with Concurrent Antiviral V-073 Administration in Mice
Diana Kouiavskaia, Marc S. Collett, Eugenia M. Dragunsky, Andrey Sarafanov, Konstantin M. Chumakov
Clinical and Vaccine Immunology Aug 2011, 18 (8) 1387-1390; DOI: 10.1128/CVI.05147-11
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