Article Figures & Data
Figures
- Fig. 1.
Relationship between CMV IgM antibody levels measured by UA/ml and endpoint antibody titer. Twofold serial dilutions were performed on six IgM-positive sera from the NHANES collection. UA/ml decreases approximately linearly with dilution. Sera with higher initial UA/ml values have higher endpoint titers, shown by enlarged black diamonds. The Vidas test cutoff for IgM positivity is 0.90 UA/ml.
- Fig. 2.
Association between CMV IgM antibody levels and CMV IgG avidity. CMV IgM-negative (white), IgM-equivocal (gray), and IgM-positive (black) serum specimens are plotted according to their IgM antibody level measured by UA/ml and their IgG avidity index. The assay cutoff for IgM positivity is 0.9 UA/ml. The avidity test cutoff used for this analysis was 0.7, marked by the dashed line.
Tables
- Table 1.
CMV IgG and IgM prevalence estimates (weighted) by age among 5,992 women from the NHANES national surveya
Age of women (yr) No. tested % positive for: CMV IgG CMV IgM 12–19 1,525 47.3 2.6 20–29 1,643 54.4 4.5 30–39 1,616 59.7 2.3 40–49 1,208 69.8 2.4 Total 5,992 57.9 3.0 ↵a Three of the IgM+ sera were IgG−; the rest were IgG+.
- Table 2.
Prevalence estimates (weighted) for CMV IgG low avidity by age among the 126 IgM+ sera from the NHANES national survey
Age of women (yr) No. tested Median % positive (95% CI) by test cutoff for low aviditya 0.8 0.7 0.6 12–19 36 67.4 (35.3–88.6) 33.0 (11.6–64.9) 12.3 (2.9–40.1) 20–29 52 30.7 (16.8–49.1) 16.5 (7.1–33.8) 10.4 (3.8–25.6) 30–49 38 17.1 (7.1–35.7) 3.1 (0.6–14.0) 3.1 (0.6–14.0) All ages 126 31.1 (20.1–44.6) 13.5 (6.1–27.5) 7.6 (3.5–15.9) ↵a P values for trends with age were 0.004, 0.048, and 0.3 for cutoff values of 0.8, 0.7, and 0.6, respectively. 95% CI, 95% confidence intervals.
- Table 3.
Low-CMV-IgG-avidity prevalence estimates (unweighted) for both CMV IgM-positive and IgM-negative sera from the NHANES survey, according to avidity test cutoff
CMV IgM status (no. tested) % prevalence of low IgG avidity (no. of specimens) by avidity test cutoff 0.80 0.70 0.60 IgM+ (126) 34.9 (44) 18.3 (23) 11.1 (14) IgM− (129) 8.5 (11) 2.3 (3) 0.8 (1) IgM+ and IgM− combined (255) 6.6 (55) 2.0 (26) 0.8 (15) - Table 4.
Association between CMV IgM antibody level and low IgG aviditya
IgM UA/ml No. of sera (total = 324) % low avidity IgM negative or equivalent, <0.90 154 1.9 0.90–1.09 50 6.0 1.10–1.29 26 15.4 1.30–1.49 29 17.2 1.50–1.99 32 40.6 ≥2.00–4.00 33 78.8 ↵a Sera are listed by increasing levels of IgM antibody, showing the proportion that were low IgG avidity. Chi-square test for trend, P < 0.0001. The 0.7 avidity test cutoff was used to define low IgG avidity.
