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CLINICAL LABORATORY IMMUNOLOGY

Characterization of Immune Responses to Capsid Protein p24 of Human Immunodeficiency Virus Type 1 and Implications for Detection

Shixing Tang, Jiangqin Zhao, Aifeng Wang, Ragupathy Viswanath, Harri Harma, Richard F. Little, Robert Yarchoan, Susan L. Stramer, Phillipe N. Nyambi, Sherwin Lee, Owen Wood, Eric Y. Wong, Xue Wang, Indira K. Hewlett
Shixing Tang
1Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892
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  • For correspondence: shixing.tang@fda.hhs.gov indira.hewlett@fda.hhs.gov
Jiangqin Zhao
1Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892
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Aifeng Wang
1Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892
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Ragupathy Viswanath
1Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892
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Harri Harma
2Laboratory of Biophysics, University of Turku, FIN-20520 Turku, Finland
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Richard F. Little
3HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
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Robert Yarchoan
3HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
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Susan L. Stramer
4American Red Cross, Biomedical Services Scientific Support Office, 9315 Gaither Road, Gaithersburg, Maryland 20877
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Phillipe N. Nyambi
5Pathology, New York University School of Medicine, New York, New York 10010
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Sherwin Lee
1Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892
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Owen Wood
1Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892
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Eric Y. Wong
1Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892
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Xue Wang
1Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892
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Indira K. Hewlett
1Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892
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  • For correspondence: shixing.tang@fda.hhs.gov indira.hewlett@fda.hhs.gov
DOI: 10.1128/CVI.00066-10
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Article Information

DOI 
https://doi.org/10.1128/CVI.00066-10
PubMed 
20534793

Published By 
American Society for Microbiology Journals
History 
  • Received February 12, 2010
  • Returned for modification March 16, 2010
  • Accepted June 2, 2010
  • Published online July 30, 2010.

Copyright & Usage 
Copyright © 2010 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (June 09, 2010).
  • You are viewing the most recent version of this article.

Author Information

  1. Shixing Tang1*,
  2. Jiangqin Zhao1,
  3. Aifeng Wang1,
  4. Ragupathy Viswanath1,
  5. Harri Harma2,
  6. Richard F. Little3,
  7. Robert Yarchoan3,
  8. Susan L. Stramer4,
  9. Phillipe N. Nyambi5,
  10. Sherwin Lee1,
  11. Owen Wood1,
  12. Eric Y. Wong1,
  13. Xue Wang1 and
  14. Indira K. Hewlett1*
  1. 1Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892
  2. 2Laboratory of Biophysics, University of Turku, FIN-20520 Turku, Finland
  3. 3HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
  4. 4American Red Cross, Biomedical Services Scientific Support Office, 9315 Gaither Road, Gaithersburg, Maryland 20877
  5. 5Pathology, New York University School of Medicine, New York, New York 10010
  • ↵* Corresponding author. Mailing address: Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Room 4NN16, 8800 Rockville Pike, Bethesda, MD 20892. Phone: (301) 827-0795. Fax: (301) 827-0998. E-mail for Shixing Tang: shixing.tang{at}fda.hhs.gov . E-mail for Indira Hewlett: indira.hewlett{at}fda.hhs.gov
  • † Supplemental material for this article may be found at http://cvi.asm.org/ .

  • ‡ The authors have paid a fee to allow immediate free access to this article.

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Characterization of Immune Responses to Capsid Protein p24 of Human Immunodeficiency Virus Type 1 and Implications for Detection
Shixing Tang, Jiangqin Zhao, Aifeng Wang, Ragupathy Viswanath, Harri Harma, Richard F. Little, Robert Yarchoan, Susan L. Stramer, Phillipe N. Nyambi, Sherwin Lee, Owen Wood, Eric Y. Wong, Xue Wang, Indira K. Hewlett
Clinical and Vaccine Immunology Jul 2010, 17 (8) 1244-1251; DOI: 10.1128/CVI.00066-10

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Characterization of Immune Responses to Capsid Protein p24 of Human Immunodeficiency Virus Type 1 and Implications for Detection
Shixing Tang, Jiangqin Zhao, Aifeng Wang, Ragupathy Viswanath, Harri Harma, Richard F. Little, Robert Yarchoan, Susan L. Stramer, Phillipe N. Nyambi, Sherwin Lee, Owen Wood, Eric Y. Wong, Xue Wang, Indira K. Hewlett
Clinical and Vaccine Immunology Jul 2010, 17 (8) 1244-1251; DOI: 10.1128/CVI.00066-10
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KEYWORDS

Epitope Mapping
HIV Antibodies
HIV Core Protein p24
HIV Infections
Immunodominant Epitopes

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