DOI: 10.1128/CVI.00414-07
ABSTRACT
The IMx, AxSym, and Architect immunoglobulin M anti-HBc assay systems for detecting hepatitis B virus e antigen-negative chronic hepatitis B virus infection were compared. Despite good intra- and interassay coefficients of variation, significantly different values and low correlation (overestimation by AxSym and underestimation by Architect) were observed. Association and cutoff values for distinguishing patients with viral replication should be established for all methods.
FOOTNOTES
- Received 15 October 2007.
- Returned for modification 29 October 2007.
- Accepted 28 November 2007.
↵▿ Published ahead of print on 12 December 2007.
- American Society for Microbiology
Performance Characteristics of Microparticle Enzyme and Chemiluminescence Immunoassays for Measurement of Anti-HBc Immunoglobulin M in Sera of Patients with HBeAg-Negative Chronic Hepatitis B Virus Infection
