Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My Cart

Main menu

  • Home
  • Articles
    • Archive
  • About the Journal
    • About CVI
    • For Librarians
    • For Advertisers
    • FAQ
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Clinical and Vaccine Immunology
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Archive
  • About the Journal
    • About CVI
    • For Librarians
    • For Advertisers
    • FAQ
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY

Evaluation of Four Whole-Cell Leptospira-Based Serological Tests for Diagnosis of Urban Leptospirosis

Alan J. A. McBride, Balbino L. Santos, Adriano Queiroz, Andréia C. Santos, Rudy A. Hartskeerl, Mitermayer G. Reis, Albert I. Ko
Alan J. A. McBride
1Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Bahia, Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Balbino L. Santos
1Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Bahia, Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Adriano Queiroz
1Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Bahia, Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andréia C. Santos
1Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Bahia, Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rudy A. Hartskeerl
2Department of Biomedical Research, Royal Tropical Institute (KIT), Amsterdam, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mitermayer G. Reis
1Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Bahia, Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Albert I. Ko
1Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Bahia, Brazil
3Division of International Medicine and Infectious Disease, Weill Medical College of Cornell University, New York, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: aik2001@med.cornell.edu
DOI: 10.1128/CVI.00217-07
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • FIG. 1.
    • Open in new tab
    • Download powerpoint
    FIG. 1.

    Sensitivities of the whole-cell Leptospira assays according to the number of days of illness. Mean sensitivity and 95% confidence intervals are shown for the MAT screening titer criterion of ≥1:100 (MT) and the EIE-IgM-Leptospirose (BM), Leptospira IgM ELISA (PB), Dri-Dot (DD), and Dip-S-Tick (DS) assays.

Tables

  • Figures
  • TABLE 1.

    Performance of four serologic assays for leptospirosis in subject groups from an urban center with highly endemic transmission in Brazil

    Assaya% Sensitivity (95% CI) for group in:% Specificity (95% CI) (n = 80)
    Acute phase (n = 96)Acute phase (n = 72)bConvalescent phase (n = 50)c
    MAT68.8 (58.4-77.6)45.8 (34.2-57.9)100.0 (91.1-100.0)100.0 (94.3-100.0)
    ELISA BM79.2 (69.4-86.5)54.2 (42.1-65.8)96.0 (85.1-99.3)95.0 (87.0-98.4)
    ELISA PB87.5 (78.8-93.1)66.7 (54.5-77.1)92.0 (79.9-97.4)87.5 (77.8-93.5)
    DD80.0 (70.3-87.2)50.0 (37.9-62.1)84.0 (70.3-92.4)95.0 (87.0-98.4)
    DS72.3 (62.0-80.8)32.9 (22.4-45.2)80.0 (65.9-89.5)100.0 (94.2-100.0)
    • ↵ a ELISA BM, EIE-IgM-Leptospirose(Bio-Manguinhos); ELISA PB, Leptospira IgM ELISA(PanBio); DS, Dip-S-Tick(PanBio); DD, LeptoTek Dri-Dot (bioMérieux); MAT, using a screening titer criterion of ≥1:100 in the microagglutination test.

    • ↵ b The acute-phase group included twenty-nine acute-phase patients and an additional 43 randomly selected patients; sera were collected <7 days from the onset of illness. CI, confidence interval.

    • ↵ c Convalescent-phase cases were randomly selected from the 96-acute-phase-patient group.

PreviousNext
Back to top
Download PDF
Citation Tools
Evaluation of Four Whole-Cell Leptospira-Based Serological Tests for Diagnosis of Urban Leptospirosis
Alan J. A. McBride, Balbino L. Santos, Adriano Queiroz, Andréia C. Santos, Rudy A. Hartskeerl, Mitermayer G. Reis, Albert I. Ko
Clinical and Vaccine Immunology Sep 2007, 14 (9) 1245-1248; DOI: 10.1128/CVI.00217-07

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Print

Email

Thank you for sharing this Clinical and Vaccine Immunology article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Evaluation of Four Whole-Cell Leptospira-Based Serological Tests for Diagnosis of Urban Leptospirosis
(Your Name) has forwarded a page to you from Clinical and Vaccine Immunology
(Your Name) thought you would be interested in this article in Clinical and Vaccine Immunology.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Evaluation of Four Whole-Cell Leptospira-Based Serological Tests for Diagnosis of Urban Leptospirosis
Alan J. A. McBride, Balbino L. Santos, Adriano Queiroz, Andréia C. Santos, Rudy A. Hartskeerl, Mitermayer G. Reis, Albert I. Ko
Clinical and Vaccine Immunology Sep 2007, 14 (9) 1245-1248; DOI: 10.1128/CVI.00217-07
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Top
  • Article
    • ABSTRACT
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

Leptospira
Leptospirosis

Related Articles

Cited By...

About

  • About CVI
  • For Librarians
  • For Advertisers
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • Submit a Manuscript to mSphere

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 1556-6811; Online ISSN: 1556-679X