Seroprevalence of Neutralizing Antibodies to Adenovirus Type 5 among Children in India: Implications for Recombinant Adenovirus-Based Vaccines

DOI: 10.1128/CVI.00173-07

Article Figures & Data

TABLE 1.

Adenovirus immunity in the children in this study

Group	Age in mo (n)	Anti-adenovirus antibodies (ELISA)			Anti-Ad5 neutralizing antibodies (PRNT)
Group	Age in mo (n)	GMT ± SD	Log₂ GMT ± SD	% Seronegative	GMT ± SD	Log₂ GMT ± SD	% Seronegative
1	<6 (16)	109.05 ± 433.88	4.6918 ± 1.4512	6	14.77 ± 51.05	2.6925 ± 0.9460	69
2	7-12 (22)	181.96 ± 1,351.86	5.2038 ± 1.5907	18	11.34 ± 6.85	2.4286 ± 0.3473	64
3	13-18 (11)	291.90 ± 663.54	5.6764 ± 1.6798	0	15.54 ± 92.95	2.7437 ± 1.0408	63
4	19-24 (21)	1,228.69 ± 15,041.80	7.1137 ± 2.5979	5	47.18 ± 462.81	3.8539 ± 1.9347	33

TABLE 2.

Scheffe's post-hoc ANOVA-based analysis of log geometric mean ELISA titers and PRNTs across four age groups^a

Age group	Group 1		Group 2		Group 3
Age group	Log₂ ELISA titer	Log₂ PRNT	Log₂ ELISA titer	Log₂ PRNT	Log₂ ELISA titer	Log₂ PRNT
2	0.51198 (0.885)	−0.26387 (0.936)
3	0.98458 (0.643)	0.05120 (1.000)	0.47260 (0.932)	0.31507 (0.924)
4	2.42189 (0.005)	1.16143 (0.056)	1.90991 (0.021)	1.42530 (0.005)	1.43731 (0.274)	1.11024 (0.134)

↵ a Shown are the differences in the geometric mean ELISA titers and PRNTs of different groups. The P values for the statistical significance of the differences between groups are in parentheses.