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VACCINE RESEARCH

Seroprevalence of Neutralizing Antibodies to Adenovirus Type 5 among Children in India: Implications for Recombinant Adenovirus-Based Vaccines

Mohan Babu Appaiahgari, Ravindra Mohan Pandey, Sudhanshu Vrati
Mohan Babu Appaiahgari
1National Institute of Immunology, New Delhi 110 067, India
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Ravindra Mohan Pandey
2Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 110 016, India
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Sudhanshu Vrati
1National Institute of Immunology, New Delhi 110 067, India
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  • For correspondence: vrati@nii.res.in
DOI: 10.1128/CVI.00173-07
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Tables

  • TABLE 1.

    Adenovirus immunity in the children in this study

    GroupAge in mo (n)Anti-adenovirus antibodies (ELISA)Anti-Ad5 neutralizing antibodies (PRNT)
    GMT ± SDLog2 GMT ± SD% SeronegativeGMT ± SDLog2 GMT ± SD% Seronegative
    1<6 (16)109.05 ± 433.884.6918 ± 1.4512614.77 ± 51.052.6925 ± 0.946069
    27-12 (22)181.96 ± 1,351.865.2038 ± 1.59071811.34 ± 6.852.4286 ± 0.347364
    313-18 (11)291.90 ± 663.545.6764 ± 1.6798015.54 ± 92.952.7437 ± 1.040863
    419-24 (21)1,228.69 ± 15,041.807.1137 ± 2.5979547.18 ± 462.813.8539 ± 1.934733
  • TABLE 2.

    Scheffe's post-hoc ANOVA-based analysis of log geometric mean ELISA titers and PRNTs across four age groupsa

    Age groupGroup 1Group 2Group 3
    Log2 ELISA titerLog2 PRNTLog2 ELISA titerLog2 PRNTLog2 ELISA titerLog2 PRNT
    20.51198 (0.885)−0.26387 (0.936)
    30.98458 (0.643)0.05120 (1.000)0.47260 (0.932)0.31507 (0.924)
    42.42189 (0.005)1.16143 (0.056)1.90991 (0.021)1.42530 (0.005)1.43731 (0.274)1.11024 (0.134)
    • ↵ a Shown are the differences in the geometric mean ELISA titers and PRNTs of different groups. The P values for the statistical significance of the differences between groups are in parentheses.

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Seroprevalence of Neutralizing Antibodies to Adenovirus Type 5 among Children in India: Implications for Recombinant Adenovirus-Based Vaccines
Mohan Babu Appaiahgari, Ravindra Mohan Pandey, Sudhanshu Vrati
Clinical and Vaccine Immunology Aug 2007, 14 (8) 1053-1055; DOI: 10.1128/CVI.00173-07

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Seroprevalence of Neutralizing Antibodies to Adenovirus Type 5 among Children in India: Implications for Recombinant Adenovirus-Based Vaccines
Mohan Babu Appaiahgari, Ravindra Mohan Pandey, Sudhanshu Vrati
Clinical and Vaccine Immunology Aug 2007, 14 (8) 1053-1055; DOI: 10.1128/CVI.00173-07
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KEYWORDS

Adenovirus Infections, Human
Adenoviruses, Human
Antibodies, Viral

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