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MICROBIAL IMMUNOLOGY

Opsonophagocytic Activity and Other Serological Indications of Bordetella pertussis Infection in Military Recruits in Norway

Audun Aase, Tove Karin Herstad, Samuel Merino, Kari Torkildsen Brandsdal, Bjørn Peter Berdal, Erja M. Aleksandersen, Ingeborg S. Aaberge
Audun Aase
1Department of Bacteriology and Immunology, Norwegian Institute of Public Health, Oslo, Norway
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  • For correspondence: audun.aase@fhi.no
Tove Karin Herstad
1Department of Bacteriology and Immunology, Norwegian Institute of Public Health, Oslo, Norway
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Samuel Merino
1Department of Bacteriology and Immunology, Norwegian Institute of Public Health, Oslo, Norway
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Kari Torkildsen Brandsdal
2General Practice Branch, Armed Forces Medical Services, Oslo, Norway
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Bjørn Peter Berdal
3Institute of Microbiology, Armed Forces Medical Services, Oslo, Norway
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Erja M. Aleksandersen
4Ullevål University Hospital, Oslo, Norway
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Ingeborg S. Aaberge
1Department of Bacteriology and Immunology, Norwegian Institute of Public Health, Oslo, Norway
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DOI: 10.1128/CVI.00081-07
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ABSTRACT

Bordetella pertussis is the causative agent of pertussis (whooping cough). Despite high vaccination coverage, pertussis remains a significant disease in many countries. Besides vaccination, transient carriage of Bordetella spp. or other cross-reacting organisms adds to the immunity against pertussis. However, the various immunological mechanisms conferring protection remain largely unknown. In this study, paired serum samples from 464 healthy Norwegian military recruits were collected, the first at enrolment and the second about 8 months later. The prevalence of pertussis during military service was examined by comparing the paired serum samples for immunoglobulin G (IgG) antibodies against pertussis toxin (PT) by enzyme-linked immunosorbent assay (ELISA). Seventy-eight percent of the recruits had low levels of IgG antibodies against PT in both samples. Conversely, 8.4% of the recruits demonstrated high anti-PT IgG levels in the first sample, indicative of recent pertussis prior to enrolment. One recruit experienced seroconversion, indicating pertussis during service. A subset of 248 serum samples with low, medium, and high anti-PT IgG titers were analyzed by a different ELISA kit for IgG and IgA antibodies against PT and filamentous hemagglutinin (FHA) and for opsonophagocytic activity (OPA), for induction of C3b deposition products, and for IgG binding with live B. pertussis as the antigen. We observed high correlations between OPA and IgG against live bacteria (r = 0.83), between OPA and IgG anti-FHA (r = 0.79), between OPA and anti-PT IgG (r = 0.68), and between OPA and C3b binding (r = 0.70) (P < 0.0001 for all). Anti-PT IgA did not correlate closely with the other assays.

  • Copyright © 2007 American Society for Microbiology
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Opsonophagocytic Activity and Other Serological Indications of Bordetella pertussis Infection in Military Recruits in Norway
Audun Aase, Tove Karin Herstad, Samuel Merino, Kari Torkildsen Brandsdal, Bjørn Peter Berdal, Erja M. Aleksandersen, Ingeborg S. Aaberge
Clinical and Vaccine Immunology Jul 2007, 14 (7) 855-862; DOI: 10.1128/CVI.00081-07

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Opsonophagocytic Activity and Other Serological Indications of Bordetella pertussis Infection in Military Recruits in Norway
Audun Aase, Tove Karin Herstad, Samuel Merino, Kari Torkildsen Brandsdal, Bjørn Peter Berdal, Erja M. Aleksandersen, Ingeborg S. Aaberge
Clinical and Vaccine Immunology Jul 2007, 14 (7) 855-862; DOI: 10.1128/CVI.00081-07
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KEYWORDS

Bordetella pertussis
Military Personnel
Pertussis Vaccine
phagocytosis
Whooping Cough

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