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CELLULAR IMMUNOLOGY, ANTIBODIES, AND MEDIATORS OF IMMUNITY

The Flavonoid Quercetin Inhibits Proinflammatory Cytokine (Tumor Necrosis Factor Alpha) Gene Expression in Normal Peripheral Blood Mononuclear Cells via Modulation of the NF-κβ System

Madhavan P. Nair, Supriya Mahajan, Jessica L. Reynolds, Ravikumar Aalinkeel, Harikrishnan Nair, Stanley A. Schwartz, Chithan Kandaswami
Madhavan P. Nair
Department of Medicine and Microbiology, Kaleida Health System, Buffalo General Hospital, State University of New York at Buffalo, Buffalo, New York 14203
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  • For correspondence: mnair@acsu.buffalo.edu
Supriya Mahajan
Department of Medicine and Microbiology, Kaleida Health System, Buffalo General Hospital, State University of New York at Buffalo, Buffalo, New York 14203
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Jessica L. Reynolds
Department of Medicine and Microbiology, Kaleida Health System, Buffalo General Hospital, State University of New York at Buffalo, Buffalo, New York 14203
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Ravikumar Aalinkeel
Department of Medicine and Microbiology, Kaleida Health System, Buffalo General Hospital, State University of New York at Buffalo, Buffalo, New York 14203
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Harikrishnan Nair
Department of Medicine and Microbiology, Kaleida Health System, Buffalo General Hospital, State University of New York at Buffalo, Buffalo, New York 14203
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Stanley A. Schwartz
Department of Medicine and Microbiology, Kaleida Health System, Buffalo General Hospital, State University of New York at Buffalo, Buffalo, New York 14203
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Chithan Kandaswami
Department of Medicine and Microbiology, Kaleida Health System, Buffalo General Hospital, State University of New York at Buffalo, Buffalo, New York 14203
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DOI: 10.1128/CVI.13.3.319-328.2006
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ABSTRACT

The flavonoids comprise a large class of low-molecular-weight plant metabolites ubiquitously distributed in food plants. These dietary antioxidants exert significant antitumor, antiallergic, and anti-inflammatory effects. The molecular mechanisms of their biological effects remain to be clearly understood. We investigated the anti-inflammatory potentials of a safe, common dietary flavonoid component, quercetin, for its ability to modulate the production and gene expression of the proinflammatory cytokine tumor necrosis factor alpha (TNF-α) by human peripheral blood mononuclear cells (PBMC). Our results showed that quercetin significantly inhibited TNF-α production and gene expression in a dose-dependent manner. Our results provide direct evidence of the anti-inflammatory effects of quercetin by PBMC, which are mediated by the inhibition of the proinflammatory cytokine TNF-α via modulation of NF-κβ1 and Iκβ.

  • Copyright © 2006 American Society for Microbiology
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The Flavonoid Quercetin Inhibits Proinflammatory Cytokine (Tumor Necrosis Factor Alpha) Gene Expression in Normal Peripheral Blood Mononuclear Cells via Modulation of the NF-κβ System
Madhavan P. Nair, Supriya Mahajan, Jessica L. Reynolds, Ravikumar Aalinkeel, Harikrishnan Nair, Stanley A. Schwartz, Chithan Kandaswami
Clinical and Vaccine Immunology Mar 2006, 13 (3) 319-328; DOI: 10.1128/CVI.13.3.319-328.2006

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The Flavonoid Quercetin Inhibits Proinflammatory Cytokine (Tumor Necrosis Factor Alpha) Gene Expression in Normal Peripheral Blood Mononuclear Cells via Modulation of the NF-κβ System
Madhavan P. Nair, Supriya Mahajan, Jessica L. Reynolds, Ravikumar Aalinkeel, Harikrishnan Nair, Stanley A. Schwartz, Chithan Kandaswami
Clinical and Vaccine Immunology Mar 2006, 13 (3) 319-328; DOI: 10.1128/CVI.13.3.319-328.2006
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KEYWORDS

Down-Regulation
Inflammation Mediators
Leukocytes, Mononuclear
NF-kappa B
Quercetin
Tumor Necrosis Factor-alpha

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