Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My Cart

Main menu

  • Home
  • Articles
    • Archive
  • About the Journal
    • About CVI
    • For Librarians
    • For Advertisers
    • FAQ
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Clinical and Vaccine Immunology
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Archive
  • About the Journal
    • About CVI
    • For Librarians
    • For Advertisers
    • FAQ
VETERINARY IMMUNOLOGY

Bovine Immune Response to Shiga-Toxigenic Escherichia coli O157:H7

Mark A. Hoffman, Christian Menge, Thomas A. Casey, William Laegreid, Brad T. Bosworth, Evelyn A. Dean-Nystrom
Mark A. Hoffman
Enteric Diseases and Food Safety Research, National Disease Center, USDA, Agriculture Research Service, Ames, Iowa 50010Cerner Corporation, Kansas City, Missouri 64117
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christian Menge
Institute for Hygiene and Infectious Diseases of Animals, Justus Liebig University, D-35392 Giessen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas A. Casey
Enteric Diseases and Food Safety Research, National Disease Center, USDA, Agriculture Research Service, Ames, Iowa 50010
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
William Laegreid
U.S. Meat Animal Research Center, USDA, Agriculture Research Service, Clay Center, Nebraska 68933
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Brad T. Bosworth
Enteric Diseases and Food Safety Research, National Disease Center, USDA, Agriculture Research Service, Ames, Iowa 50010Novartis Animal Health US, Greensboro, North Carolina 27408
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Evelyn A. Dean-Nystrom
Enteric Diseases and Food Safety Research, National Disease Center, USDA, Agriculture Research Service, Ames, Iowa 50010
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: enystrom@nadc.ars.usda.gov
DOI: 10.1128/CVI.00205-06
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

ABSTRACT

Although cattle develop humoral immune responses to Shiga-toxigenic (Stx+) Escherichia coli O157:H7, infections often result in long-term shedding of these human pathogenic bacteria. The objective of this study was to compare humoral and cellular immune responses to Stx+ and Stx− E. coli O157:H7. Three groups of calves were inoculated intrarumenally, twice in a 3-week interval, with different strains of E. coli: a Stx2-producing E. coli O157:H7 strain (Stx2+O157), a Shiga toxin-negative E. coli O157:H7 strain (Stx−O157), or a nonpathogenic E. coli strain (control). Fecal shedding of Stx2+O157 was significantly higher than that of Stx−O157 or the control. Three weeks after the second inoculation, all calves were challenged with Stx2+O157. Following the challenge, levels of fecal shedding of Stx2+O157 were similar in all three groups. Both groups inoculated with an O157 strain developed antibodies to O157 LPS. Calves initially inoculated with Stx−O157, but not those inoculated with Stx2+O157, developed statistically significant lymphoproliferative responses to heat-killed Stx2+O157. These results provide evidence that infections with STEC can suppress the development of specific cellular immune responses in cattle, a finding that will need to be addressed in designing vaccines against E. coli O157:H7 infections in cattle.

FOOTNOTES

    • Received 2 June 2006.
    • Returned for modification 1 August 2006.
    • Accepted 5 October 2006.
  • ↵▿ Published ahead of print on 18 October 2006.

  • American Society for Microbiology
View Full Text
PreviousNext
Back to top
Download PDF
Citation Tools
Bovine Immune Response to Shiga-Toxigenic Escherichia coli O157:H7
Mark A. Hoffman, Christian Menge, Thomas A. Casey, William Laegreid, Brad T. Bosworth, Evelyn A. Dean-Nystrom
Clinical and Vaccine Immunology Dec 2006, 13 (12) 1322-1327; DOI: 10.1128/CVI.00205-06

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Print

Email

Thank you for sharing this Clinical and Vaccine Immunology article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Bovine Immune Response to Shiga-Toxigenic Escherichia coli O157:H7
(Your Name) has forwarded a page to you from Clinical and Vaccine Immunology
(Your Name) thought you would be interested in this article in Clinical and Vaccine Immunology.
Share
Bovine Immune Response to Shiga-Toxigenic Escherichia coli O157:H7
Mark A. Hoffman, Christian Menge, Thomas A. Casey, William Laegreid, Brad T. Bosworth, Evelyn A. Dean-Nystrom
Clinical and Vaccine Immunology Dec 2006, 13 (12) 1322-1327; DOI: 10.1128/CVI.00205-06
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Top
  • Article
    • ABSTRACT
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

Cited By...

About

  • About CVI
  • For Librarians
  • For Advertisers
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • Submit a Manuscript to mSphere

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

Copyright © 2019 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 1556-6811; Online ISSN: 1556-679X