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CELLULAR IMMUNOLOGY, ANTIBODIES, AND MEDIATORS OF IMMUNITY

Analysis of Plasmacytoid and Myeloid Dendritic Cells in Nasal Epithelium

Evelyn Hartmann, Hendrik Graefe, Anne Hopert, Ralph Pries, Simon Rothenfusser, Hendrik Poeck, Brigitte Mack, Stefan Endres, Gunther Hartmann, Barbara Wollenberg
Evelyn Hartmann
1Department of Otorhinolaryngology, University of Munich, Munich, Germany
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Hendrik Graefe
4Department of Otorhinolaryngology, University of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany
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Anne Hopert
4Department of Otorhinolaryngology, University of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany
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Ralph Pries
4Department of Otorhinolaryngology, University of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany
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Simon Rothenfusser
3Department of Internal Medicine and Division of Clinical Pharmacology, University of Munich, Munich, Germany
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Hendrik Poeck
3Department of Internal Medicine and Division of Clinical Pharmacology, University of Munich, Munich, Germany
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Brigitte Mack
1Department of Otorhinolaryngology, University of Munich, Munich, Germany
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Stefan Endres
3Department of Internal Medicine and Division of Clinical Pharmacology, University of Munich, Munich, Germany
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Gunther Hartmann
2Department of Clinical Pharmacology, University of Bonn, Bonn, Germany
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Barbara Wollenberg
4Department of Otorhinolaryngology, University of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany
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  • For correspondence: Barbara.Wollenberg@hno.uni-luebeck.de
DOI: 10.1128/CVI.00172-06
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ABSTRACT

The role of plasmacytoid dendritic cells (PDC), the major producers of alpha interferon upon viral infection, in the nasal mucosa is largely unknown. Here we examined the presence of PDC together with myeloid dendritic cells (MDC) in the nasal epithelia of healthy individuals, of asymptomatic patients with chronic nasal allergy, of patients undergoing steroid therapy, and of patients with infectious rhinitis or rhinosinusitis. Considerable numbers of PDC and MDC could be detected in the nasal epithelium. Furthermore, we demonstrate the expression of SDF-1, the major chemoattractant for PDC, in the nasal epithelium. PDC levels were significantly lower for patients with allergies than for healthy individuals. Interestingly, PDC and MDC were almost absent from patients who received treatment with glucocorticoids, while very high numbers of PDC were found for patients with recent upper respiratory tract infections. Our results demonstrate for the first time a quantitative analysis of PDC and MDC in the healthy nasal epithelium and in nasal epithelia from patients with different pathological conditions. With the identification of PDC, the major target cell for CpG DNA or immunostimulatory RNA, in the nasal epithelium, this study forms the basis for a local nasal application of such oligonucleotides for the treatment of viral infection and allergy.

  • Copyright © 2006 American Society for Microbiology
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Analysis of Plasmacytoid and Myeloid Dendritic Cells in Nasal Epithelium
Evelyn Hartmann, Hendrik Graefe, Anne Hopert, Ralph Pries, Simon Rothenfusser, Hendrik Poeck, Brigitte Mack, Stefan Endres, Gunther Hartmann, Barbara Wollenberg
Clinical and Vaccine Immunology Nov 2006, 13 (11) 1278-1286; DOI: 10.1128/CVI.00172-06

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Analysis of Plasmacytoid and Myeloid Dendritic Cells in Nasal Epithelium
Evelyn Hartmann, Hendrik Graefe, Anne Hopert, Ralph Pries, Simon Rothenfusser, Hendrik Poeck, Brigitte Mack, Stefan Endres, Gunther Hartmann, Barbara Wollenberg
Clinical and Vaccine Immunology Nov 2006, 13 (11) 1278-1286; DOI: 10.1128/CVI.00172-06
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KEYWORDS

Dendritic Cells
myeloid cells
Nasal Mucosa

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