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MICROBIAL IMMUNOLOGY

Distinct Elevation of Levels of Anti-Caenorhabditis elegans Antibody in Sera of Patients with Inflammatory Bowel Disease

Nobuhide Oshitani, Fumihiko Hato, Seiichi Kitagawa, Kenji Watanabe, Yasuhiro Fujiwara, Kazuhide Higuchi, Takayuki Matsumoto, Tetsuo Arakawa
Nobuhide Oshitani
1Department of Gastroenterology
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  • For correspondence: nobu@med.osaka-cu.ac.jp
Fumihiko Hato
2Second Department of Physiology, Osaka City University Graduate School of Medicine, Osaka 545-8585 Japan
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Seiichi Kitagawa
2Second Department of Physiology, Osaka City University Graduate School of Medicine, Osaka 545-8585 Japan
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Kenji Watanabe
1Department of Gastroenterology
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Yasuhiro Fujiwara
1Department of Gastroenterology
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Kazuhide Higuchi
1Department of Gastroenterology
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Takayuki Matsumoto
1Department of Gastroenterology
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Tetsuo Arakawa
1Department of Gastroenterology
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DOI: 10.1128/CDLI.10.5.856-861.2003
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  • FIG. 1.
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    FIG. 1.

    IgG ACEA titers in healthy controls, patients with IBD, and patients with intestinal Behçet's disease. IgG ACEA titers were significantly higher in patients with IBD than in controls. Error bars indicate standard deviations.

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    FIG. 2.

    IgG ACEA and 5-aminosalicylate derivatives. Patients with CD taking sulfasalazine or mesalazine had significantly lower IgG ACEA titers than patients with CD not taking these drugs. n.s., not significant. Error bars indicate standard deviations.

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    FIG. 3.

    IgG subclass ACEA titers in healthy controls, patients with IBD, and patients with intestinal Behçet's disease. IgG2 ACEA titers were significantly higher in patients with IBD and intestinal Behçet's disease than in controls. IgG3 ACEA titers were significantly higher in patients with CD than in patients with UC. Error bars indicate standard deviations.

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    FIG. 4.

    IgG subclass ACEA titers and disease involvement in patients with IBD. IgG3 ACEA titers were significantly higher for CD colitis than for total and left-sided UC and were significantly higher for CD ileitis than for left-sided UC. Error bars indicate standard deviations.

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    FIG. 5.

    IgG subclass ACEA titers and 5-aminosalicylate derivatives. IgG2 ACEA titers were significantly lower in patients with CD taking either sulfasalazine or mesalazine than in patients not taking these drugs. Error bars indicate standard deviations.

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  • TABLE 1.

    Clinical features of patients with UC and CD

    CharacteristicValue for group
    UCCD
    No. of patients2930
    Male/female12/1715/15
    Mean age; range (yr)35; 20-5531; 18-67
    Active/quiescent10/1915/15
    Disease location
        Small bowel6
        Large bowel10
        Small and large bowel14
        Left-sided colitis29
        Total colitis9
    Medical treatment
        Sulfasalazine or mesalazine2319
        Corticosteroids98
        Dietary therapy016
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Distinct Elevation of Levels of Anti-Caenorhabditis elegans Antibody in Sera of Patients with Inflammatory Bowel Disease
Nobuhide Oshitani, Fumihiko Hato, Seiichi Kitagawa, Kenji Watanabe, Yasuhiro Fujiwara, Kazuhide Higuchi, Takayuki Matsumoto, Tetsuo Arakawa
Clinical and Diagnostic Laboratory Immunology Sep 2003, 10 (5) 856-861; DOI: 10.1128/CDLI.10.5.856-861.2003

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Distinct Elevation of Levels of Anti-Caenorhabditis elegans Antibody in Sera of Patients with Inflammatory Bowel Disease
Nobuhide Oshitani, Fumihiko Hato, Seiichi Kitagawa, Kenji Watanabe, Yasuhiro Fujiwara, Kazuhide Higuchi, Takayuki Matsumoto, Tetsuo Arakawa
Clinical and Diagnostic Laboratory Immunology Sep 2003, 10 (5) 856-861; DOI: 10.1128/CDLI.10.5.856-861.2003
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