Article Figures & Data
Figures
- FIG. 1.
Efficacy predicted on the basis of the proportions of unvaccinated and vaccinated individuals with titers below the different rSBA cutoffs measured 1 month following vaccination with the MCC vaccine.
- FIG. 2.
Efficacy predicted on the basis of the proportions of unvaccinated and vaccinated individuals with titers below the different rSBA cutoffs measured 9 months (infants) or 7 months (toddlers) months following vaccination with the MCC vaccine.
Tables
- TABLE 1.
Distribution of rSBA titers after vaccination with MCC vaccine by age when vaccination was completed and time since vaccination
SBA titer No. of individuals at the indicated times postvaccination: Infants (age, 4-5 mo) Toddlers (age, 12-14 mo) Preschool children (age, 3-4 yr), 1 mo 1 mo 9 mo 1 mo 7 mo <4 0 13 3 10 0 4 1 10 3 6 0 8 0 3 3 0 3 16 0 3 3 6 2 32 0 4 7 9 1 64 1 3 4 3 6 128+ 51 14 47 31 110 Total 53 50 70 65 122 - TABLE 2.
Distribution of rSBA titers in an unvaccinated population
SBA titer No. of individuals Infants (age, 3-11 mo) Toddlers (age, 12-23 mo) Preschool children (age, 2-4 yr) <4 142 225 189 4 6 8 6 8 5 11 2 16 5 4 2 32 2 6 4 64 3 4 1 128+ 6 9 5 Total 169 267 209 - TABLE 3.
Predicted vaccine efficacy and 95% CIs estimated for unvaccinated and vaccinated children with titers below the different SBA cutoffs 1 month after vaccination with the MCC vaccine measured by SBA
Group and cutoff % Individuals with titers below cutoff Predicted % vaccine efficacy (95% CI) Vaccinated Unvaccinated Infants 1:4 0.0 84.0 100 (86-100) 1:8 1.9 87.6 98 (85-100) 1:16 1.9 90.5 98 (86-100) 1:32 1.9 93.5 98 (84-100) 1:64 1.9 94.7 98 (86-100) 1:128 3.8 96.4 96 (85-99) Toddlers 1:4 4.3 84.3 95 (85-98) 1:8 8.6 87.3 90 (79-95) 1:16 12.9 91.4 86 (74-92) 1:32 17.1 92.9 82 (69-89) 1:64 27.1 95.1 71 (58-81) 1:128 32.9 96.6 66 (52-76) Preschool children 1:4 0.0 90.4 100 (95-100) 1:8 0.0 93.3 100 (95-100) 1:16 2.5 94.3 97 (92-99) 1:32 4.1 95.2 96 (90-98) 1:64 4.9 97.1 95 (89-98) 1:128 9.8 97.6 90 (83-94) - TABLE 4.
Predicted vaccine efficacy and 95% CIs estimated for unvaccinated and vaccinated infants and toddlers with titers below the different SBA cutoffs 7 to 9 months after vaccination with the MCC vaccine measured by SBA
Group and cutoff % Individuals with titers below cutoff Predicted % vaccine efficacy (95% CI) Vaccinated Unvaccinated Infants 1:4 26.0 84.0 69 (50-81) 1:8 46.0 87.6 47 (29-61) 1:16 52.0 90.5 43 (25-56) 1:32 58.0 93.5 38 (21-51) 1:64 66.0 94.7 30 (15-43) 1:128 72.0 96.4 24 (9-36) Toddlers 1:4 15.4 84.3 82 (68-90) 1:8 24.6 87.3 72 (57-82) 1:16 24.6 91.4 73 (59-82) 1:32 33.8 92.9 64 (49-74) 1:64 47.7 95.1 50 (35-61) 1:128 52.3 96.6 46 (32-57)
