CVI Accepts, published online ahead of print on 18 March 2009

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Clin. Vaccine Immunol. doi:10.1128/CVI.00432-08
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

HN glycoprotein of Newcastle disease virus expressed in Rachiplusia nu larvae: its potential use as immunogen for chickens

Silvina Chimeno Zoth, Evangelina Gómez, Juan Manuel Carballeda, Oscar Taboga, Elisa Carrillo, and Analía Berinstein^*

Instituto de Biotecnología, CICVyA, INTA, Castelar, Cc 25 B1712WAA, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Rivadavia 1917 C1033AAJ, Ciudad de Buenos Aires, Argentina

^* To whom correspondence should be addressed. Email: aberinstein{at}cnia.inta.gov.ar.

The hemagglutinin-neuraminidase (HN) glycoprotein of Newcastle disease virus (NDV) was obtained as a recombinant antigen in Rachiplusia nu larvae. When used as immunogen in chickens, a solid immune response, including neutralizing antibodies, was detected, demonstrating the potential use of this simple and economic strategy in the design of recombinant anti-NDV vaccines.