CVI Accepts, published online ahead of print on 19 November 2008
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ASM journals
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by López-Álvarez, M. R.
Right arrow Articles by Minguela, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by López-Álvarez, M. R.
Right arrow Articles by Minguela, A.

 Previous Article  |  Next Article 

Clin. Vaccine Immunol. doi:10.1128/CVI.00358-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Monoclonal expansion of EBV-negative CD158a+ NK cells secreting high amounts of IFN-{gamma} associated with hemophagocytic lymphohistiocytosis

María R. López-Álvarez, María V. Martínez-Sánchez, María G. Salgado-Cecilia, José A. Campillo, Damian Heine-Suñer, Florentina Villar-Permuy, José L. Fuster, Águeda Bas, Juana Gil-Herrera, Manuel Muro, Ana M. García-Alonso, María R. Álvarez-López, and Alfredo Minguela*

Inmunology, Pediatric Oncology, and Pathology Services, Hospital U. Virgen de la Arrixaca, Murcia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd). Molecular Genetics, Hospital U. Son Dureta, Palma de Mallorca, Spain; Inmunology Service, Hospital Gregorio Marañón, Madrid, Spain

* To whom correspondence should be addressed. Email: alfredo.minguela{at}carm.es.


arrow
Abstract

We report the first case of hemophagocytic lymphohistiocytosis (HLH) induced by the monoclonal expansion of EBV-negative NK-cells. Consanguinity of parents made it necessary to discard familial HLH in patient and HLA-identical sister and demonstrate that no cause other than the expansion of NK-cells, highly secretory of IFN-{gamma}, was the inducer.






Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»