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CVI Accepts, published online ahead of print on 1 August 2007
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Clin. Vaccine Immunol. doi:10.1128/CVI.00356-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Measuring Recent Human Immunodeficiency Virus Type 1 Infections in China

Yao Xiao, Yan Jiang*, Jigang Feng, Wenyan Xu, Minjie Wang, Ellen Funkhouser, Sten H. Vermund, and Yujiang Jia*

National AIDS Reference Laboratory, National Center for AIDS & STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, P. R. China, Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL 35294-0022, USA, Institute for Global Health and Department of Pediatrics, School of Medicine, Vanderbilt University, Nashville, TN 37232-0242, USA

* To whom correspondence should be addressed. Email: jiangyan03{at}263.net. yujiang.jia{at}vanderbilt.edu.


   Abstract

A subtype B, E, and D immunoglobulin G capture immunoassay shows promise as a tool for estimating human immunodeficiency virus type 1 (HIV-1) seroincidence from cross-sectional surveys, but the test-specific limitations suggest that an adjustment is necessary and further validation of the assay in populations with divergent subtypes are needed.




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