CVI Accepts, published online ahead of print on 21 October 2009
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Clin. Vaccine Immunol. doi:10.1128/CVI.00314-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Monocyte-derived interleukin-10 depresses the Bordetella pertussis-specific IFN-{gamma} response in vaccinated infants

V. Dirix, V. Verscheure, T. Goetghebuer, M. Hainaut, A. S. Debrie, C. Locht, and F. Mascart*

Laboratory of Vaccinology and Mucosal Immunity, Immunobiology Clinic, Hôpital Erasme; Department of Pediatrics, Hôpital Saint-Pierre; Université Libre de Bruxelles (ULB), Brussels, Belgium; INSERM U629, F-59019 Lille, France; Institut Pasteur de Lille, F-59019 Lille, France

* To whom correspondence should be addressed. Email: fmascart{at}ulb.ac.be.


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Abstract

Antigen-specific interferon-gamma (IFN-{gamma}) has been demonstrated to participate in protection against Bordetella pertussis infection. Circulating mononuclear cells from B. pertussis-infected and from pertussis-vaccinated infants secrete high amounts of IFN-{gamma} after in vitro stimulation by B. pertussis antigens, but with a large variation in the secreted IFN-{gamma} levels between individuals. We show here that the inhibition of the specific IFN-{gamma} response can be at least partially attributed to an IL-10 secretion by monocytes. This IL-10 secretion was not associated with polymorphisms at positions -1082, -819 and -592 of the IL-10 gene promoter, suggesting that other genetic or environmental factors affect the IL-10 expression and secretion.




This article has been cited by other articles:

  • Vermeulen, F., Verscheure, V., Damis, E., Vermeylen, D., Leloux, G., Dirix, V., Locht, C., Mascart, F. (2010). Cellular Immune Responses of Preterm Infants after Vaccination with Whole-Cell or Acellular Pertussis Vaccines. CVI 17: 258-262 [Abstract] [Full Text]  


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