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CVI Accepts, published online ahead of print on 8 November 2006
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CVI.00289-06v1
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Clin. Vaccine Immunol. doi:10.1128/CVI.00289-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Accuracy of ELISA using crude and purified antigens for the serodiagnosis of melioidosis

Narisara Chantratita*, Vanaporn Wuthiekanun, Aunchalee Thanwisai, Direk Limmathurotsakul, Allen C. Cheng, Wirongrong Chierakul, Nicholas P.J. Day, and Sharon J. Peacock

Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia; Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, UK

* To whom correspondence should be addressed. Email: narisara{at}tropmedres.ac,


  Abstract

Five ELISAs developed to detect antibodies to different B. pseudomallei antigen preparations were evaluated as diagnostic tests for melioidosis in northeast Thailand. The highest diagnostic indices were observed for an affinity-purified antigen (sensitivity 82%, specificity 72%) and crude B. pseudomallei antigen (sensitivity 81%, specificity 70%), an improvement over the IHA (sensitivity 73%, specificity 64%).


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