CVI Accepts, published online ahead of print on 12 November 2008
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Clin. Vaccine Immunol. doi:10.1128/CVI.00220-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Detection of West Nile Virus-Neutralizing Antibodies in Avian and Equine Serum Using a Surrogate Chimeric Virus

Nicholas Komar*, Stanley Langevin, and Thomas P. Monath

Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, Fort Collins, Colorado; Acambis, Incorporated, Cambridge, Massachusetts

* To whom correspondence should be addressed. Email: nkomar{at}cdc.gov.


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Abstract

A chimeric yellow fever/West Nile virus was compared to West Nile virus (WNV) alone as a biosafety-level-2 reagent in the plaque reduction neutralization test for determining WNV infection histories. Concordance was 96.3% among 188 avian and equine serum samples. Neutralizing antibody titers were frequently >2-fold lower using the chimera.






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