CVI Accepts, published online ahead of print on 25 July 2007

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Clin. Vaccine Immunol. doi:10.1128/CVI.00217-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Evaluation of Four Whole-Cell Leptospira-Based Serological Tests for the Diagnosis of Urban Leptospirosis

Alan J.A. McBride, Balbino L. Santos, Adriano Queiroz, Andréia C. Santos, Rudy A. Hartskeerl, Mitermayer G. Reis, and Albert I. Ko^*

Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Brazil; Dept. Biomedical Research, Royal Tropical Institute (KIT), Amsterdam, The Netherlands; and Division of International Medicine and Infectious Disease, Weill Medical College of Cornell University, New York, USA

^* To whom correspondence should be addressed. Email: aik2001{at}med.cornell.edu.

Four serologic assays for leptospirosis had a sensitivity of 72-88% and specificity of 88-100% in the setting of high endemic urban transmission, indicating that these assays in ELISA and rapid formats may be used as an alternative to the microscopic agglutination test for urban leptospirosis. Testing of a second sample will be required in cases with an initial negative result since sensitivity was low (46-68%) during the first week of illness.