CVI Accepts, published online ahead of print on 12 November 2008
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Clin. Vaccine Immunol. doi:10.1128/CVI.00215-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Common and Specific HLA-DRB1/DQB1 Haplotypes Influence the Genetic Susceptibility to Type 1 Diabetes in Three Distinct Arab Populations

Mouna Stayoussef, Jihen Jatta, Fayza A. Al-Jenaidi, Rita Nemr, Muhallab E. Ali, Touhami Mahjoub, and Wassim Y. Almawi*

Faculty of Pharmacy, University of Monastir, Monastir, Tunisia; College of Medicine and Medical Sciences, Arabian Gulf University, Department of Pediatrics, Salmaniya Medical Complex, Manama, Bahrain; Department of Endocrinology, Rizk Hospital, Beirut, Lebanon

* To whom correspondence should be addressed. Email: wassim{at}agu.edu.bh.


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Abstract

HLA DRB-DQB contribution to type 1 diabetes (T1D) was investigated in Bahraini, Lebanese, and Tunisians. DRB1*030101-DQB1*0201 was susceptible in three populations, while DRB1*040101-DQB1*0302 was susceptible only in Tunisians and Bahrainis; DRB1*100101-DQB1*050101 (Bahrainis), and DRB1*150101-DQB1*060101 (Lebanese) were largely protective. HLA contribution to T1D must be evaluated with regards to ethnic background.




This article has been cited by other articles:

  • Stayoussef, M., Benmansour, J., Al-Irhayim, A.-Q., Said, H. B., Rayana, C. B., Mahjoub, T., Almawi, W. Y. (2009). Autoimmune Type 1 Diabetes Genetic Susceptibility Encoded by Human Leukocyte Antigen DRB1 and DQB1 Genes in Tunisia. CVI 16: 1146-1150 [Abstract] [Full Text]  


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