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 Previous Article

Clinical and Vaccine Immunology, May 2009, p. 779-783, Vol. 16, No. 5
1071-412X/09/$08.00+0     doi:10.1128/CVI.00029-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Development and Characterization of Mouse Models of Infection with Aerosolized Brucella melitensis and Brucella suis{triangledown}

Sophie J. Smither,* Stuart D. Perkins, Carwyn Davies, Anthony J. Stagg, Michelle Nelson, and Helen S. Atkins

Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom

Received 21 January 2009/ Returned for modification 8 March 2009/ Accepted 17 March 2009

There is a need to identify vaccines that can protect against Brucella, a potential bioterrorism agent. We have developed mouse models of infection with aerosolized Brucella melitensis and Brucella suis and demonstrated their utility for the evaluation of vaccines using the model live B. melitensis vaccine strain Rev.1.

* Corresponding author. Mailing address: Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom. Phone: 44(0)1980 614758. Fax: 44(0)1980 614307. E-mail: sjsmither{at}dstl.gov.uk

{triangledown} Published ahead of print on 25 March 2009.

Clinical and Vaccine Immunology, May 2009, p. 779-783, Vol. 16, No. 5
1071-412X/09/$08.00+0     doi:10.1128/CVI.00029-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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