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Clinical and Vaccine Immunology, February 2009, p. 285-287, Vol. 16, No. 2
1071-412X/09/$08.00+0     doi:10.1128/CVI.00363-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Difference between the Abilities of Human Fc{gamma} Receptor-Expressing CV-1 Cells To Neutralize American and Asian Genotypes of Dengue Virus 2{triangledown}

W. W. I. S. Rodrigo,1 D. C. Alcena,2 Z. Kou,3 T. J. Kochel,4 K. R. Porter,5 G. Comach,6 R. C. Rose,2,3 X. Jin,2,3 and J. J. Schlesinger2,3*

Departments of Pathology and Laboratory Medicine,1 Microbiology and Immunology,2 Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York,3 Naval Medical Research Center Detachment, Lima, Peru,4 U.S. Naval Medical Research Center, Silver Spring, Maryland,5 Laboratorio Regional de Diagnostico e Investigacion del Dengue y otras Enfermedades Virales (Lardidev), Maracay Estado Aragua, Venezuela6

Received 2 October 2008/ Returned for modification 4 November 2008/ Accepted 17 November 2008

Sera from patients involved in a Peruvian outbreak of dengue virus serotype 1 infection cross-neutralized the American genotype of dengue virus serotype 2 up to 100-fold more efficiently than they did the virulent Asian genotype of dengue virus serotype 2, as determined by a plaque reduction neutralization test (PRNT) with CV-1 fibroblasts modified to express human Fc{gamma} receptor CD32. The concordant preferential immune enhancement of the Asian genotype of dengue virus serotype 2 in human monocytes suggests that such a modification might strengthen the correlation between the PRNT titer and protection.

* Corresponding author. Mailing address: Infectious Diseases Division, Department of Medicine, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, NY 14642. Phone: (585) 275-5871. Fax: (585) 442-9328. E-mail: jacob_schlesinger{at}urmc.rochester.edu

{triangledown} Published ahead of print on 26 November 2008.

Clinical and Vaccine Immunology, February 2009, p. 285-287, Vol. 16, No. 2
1071-412X/09/$08.00+0     doi:10.1128/CVI.00363-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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