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Clinical and Vaccine Immunology, January 2009, p. 136-138, Vol. 16, No. 1
1071-412X/09/$08.00+0     doi:10.1128/CVI.00215-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Influence of Common and Specific HLA-DRB1/DQB1 Haplotypes on Genetic Susceptibilities of Three Distinct Arab Populations to Type 1 Diabetes{triangledown}

Mouna Stayoussef,1 Jihen Benmansour,1 Fayza A. Al-Jenaidi,2,3 Rita Nemr,4 Muhallab E. Ali,2 Touhami Mahjoub,1 and Wassim Y. Almawi2*

Faculty of Pharmacy, University of Monastir, Monastir, Tunisia,1 College of Medicine and Medical Sciences, Arabian Gulf University,2 Department of Pediatrics, Salmaniya Medical Complex, Manama, Bahrain,3 Department of Endocrinology, Rizk Hospital, Beirut, Lebanon4

Received 11 June 2008/ Returned for modification 9 October 2008/ Accepted 15 October 2008

The contribution of HLA DRB-DQB to type 1 diabetes (T1D) in Bahrainis, Lebanese, and Tunisians was investigated. DRB1*030101-DQB1*0201 was a locus that conferred susceptibility in three populations, while DRB1*040101-DQB1*0302 was a locus that conferred susceptibility only in Tunisians and Bahrainis. The DRB1*100101-DQB1*050101 (Bahrainis) and DRB1*150101-DQB1*060101 (Lebanese) loci were largely protective. The contribution of HLA to T1D must be evaluated with regard to ethnic background.

* Corresponding author. Mailing address: Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, P.O. Box 22979, Manama, Bahrain. Phone: 973-39717118. Fax: 973-17271090. E-mail: wassim{at}agu.edu.bh

{triangledown} Published ahead of print on 12 November 2008.

Clinical and Vaccine Immunology, January 2009, p. 136-138, Vol. 16, No. 1
1071-412X/09/$08.00+0     doi:10.1128/CVI.00215-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Stayoussef, M., Benmansour, J., Al-Irhayim, A.-Q., Said, H. B., Rayana, C. B., Mahjoub, T., Almawi, W. Y. (2009). Autoimmune Type 1 Diabetes Genetic Susceptibility Encoded by Human Leukocyte Antigen DRB1 and DQB1 Genes in Tunisia. CVI 16: 1146-1150 [Abstract] [Full Text]  


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