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Clinical and Vaccine Immunology, September 2008, p. 1489-1493, Vol. 15, No. 9
1071-412X/08/$08.00+0     doi:10.1128/CVI.00187-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Circulating 20S Proteasome Levels in Patients with Mixed Connective Tissue Disease and Systemic Lupus Erythematosus{triangledown}

Matthias Majetschak,1,2 Magdalena Perez,3 Luis T. Sorell,2 Janet Lam,2 Marcos E. Maldonado,3 and Robert W. Hoffman3*

The Burn and Shock Trauma Institute and Department of Surgery, Loyola University Chicago Stritch School of Medicine, Chicago, Illinois,1 Division of Trauma and Surgical Critical Care—Trauma Research, DeWitt Daughtry Family Department of Surgery,2 Division of Rheumatology and Immunology, Department of Medicine, University of Miami Miller School of Medicine, and the Miami Veteran Affairs Medical Center, Miami, Florida3

Received 25 May 2008/ Returned for modification 16 June 2008/ Accepted 18 July 2008

The associations of circulating 20S proteasomes (c20S) with clinical and serologic disease indices in patients with systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD) are unknown. We present the initial report that c20S levels are elevated in MCTD and correlate with clinically relevant changes in disease activity in SLE and MCTD.

* Corresponding author. Mailing address: Division of Rheumatology and Immunology, Department of Medicine, University of Miami Miller School of Medicine and the Miami Veteran Affairs Medical Center, 1120 N.W. 14th Street, Suite 968, Miami, FL 33136. Phone: (305) 243-6866. Fax: (305) 243-7546. E-mail: rhoffman{at}med.miami.edu

{triangledown} Published ahead of print on 30 July 2008.

Clinical and Vaccine Immunology, September 2008, p. 1489-1493, Vol. 15, No. 9
1071-412X/08/$08.00+0     doi:10.1128/CVI.00187-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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