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Clinical and Vaccine Immunology, September 2008, p. 1485-1488, Vol. 15, No. 9
1071-412X/08/$08.00+0     doi:10.1128/CVI.00131-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Impaired Gamma Interferon Response to Mycobacterium vaccae Antigens in Patients with Cavitary Pulmonary Tuberculosis{triangledown}

Elisabeth Rodríguez-Güell,1 Gemma Agustí,1 Mercè Corominas,2 Marina Luquin,1 and Esther Julián1*

Departament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, 08193, Bellaterra, Catalonia, Spain,1 Servei d'Al·lèrgia, Hospital Universitari de Bellvitge, 08907, L'Hospitalet de Llobregat, Catalonia, Spain2

Received 13 April 2008/ Returned for modification 11 June 2008/ Accepted 27 June 2008

The ability of tuberculosis patients to recognize Mycobacterium vaccae-specific antigens before starting chemotherapy and according to disease severity was analyzed. We report that the M. vaccae cell wall skeleton fraction triggers more enhanced cytokine production than the whole bacterium. Moreover, a tendency was observed for a lower gamma interferon/interleukin-10 ratio in patients with cavitary disease induced by M. vaccae antigens.

* Corresponding author. Mailing address: Departament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Facultat de Biociències, 08193 Bellaterra, Barcelona, Spain. Phone: 34 93 5813096. Fax: 34 93 5812387. E-mail: esther.julian{at}uab.es

{triangledown} Published ahead of print on 2 July 2008.

Clinical and Vaccine Immunology, September 2008, p. 1485-1488, Vol. 15, No. 9
1071-412X/08/$08.00+0     doi:10.1128/CVI.00131-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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